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Mouse Anti-human CD4/PE Conjugated antibody (bsm-30093M-PE)
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大包裝/詢價
產(chǎn)品編號 bsm-30093M-PE
英文名稱 Mouse Anti-human CD4/PE Conjugated antibody
中文名稱 PE標(biāo)記的小鼠抗人CD4單克隆抗體
別    名 LHR; BA-1; CD 44; CD44 antigen; CD44 molecule; CD44_HUMAN; CDw44; Cell surface glycoprotein CD44; chondroitin sulfate proteoglycan 8; ECMR-III; Epican; Extracellular matrix receptor III; GP90 lymphocyte homing/adhesion receptor; hematopoietic cell E- and L-selectin ligand; Heparan sulfate proteoglycan; Hermes antigen; homing function and Indian blood group system; HSA; HUTCH-I; HUTCH1; Hyaluronate receptor; MDU2; MDU3; MIC4; MUTCH1; PGP-1; PGP1; Phagocytic glycoprotein 1; Phagocytic glycoprotein I; CD44 antigen isoform 1 precursor.  
規(guī)格價格 25T/260元 購買    50T/420元 購買    100T/680元 購買    大包裝/詢價
說 明 書 25T  50T  100T
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  細(xì)胞表面分子  t-淋巴細(xì)胞  
抗體來源 Mouse
克隆類型 Monoclonal
克 隆 號 HIT4a
交叉反應(yīng)
產(chǎn)品應(yīng)用 Flow-Cyt=10ul/Test 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
免 疫 原 KLH conjugated synthetic peptide derived from human CD4
亞    型 Mouse IgG2b
純化方法 affinity purified by Protein G
儲 存 液 0.01M PBS, 0.5%BSA, 0.03% Proclin300
保存條件 Store at 2-8℃. Protect from light. Avoid freezing.
產(chǎn)品介紹 background:
This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010].

Function:
Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.

Subunit:
Associates with LCK. Binds to HIV-1 gp120 and to P4HB/PDI and upon HIV-1 binding to the cell membrane, is part of P4HB/PDI-CD4-CXCR4-gp120 complex. Interacts with HIV-1 Envelope polyprotein gp160 and protein Vpu. Interacts with Human Herpes virus 7 capsid proteins. Interacts with PTK2/FAK1; this interaction requires the presence of HIV-1 gp120.

Subcellular Location:
Cell membrane; Single-pass type I membrane protein. Note=Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.

Post-translational modifications:
Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.

Similarity:
Contains 3 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Database links:


Entrez Gene: 920 Human

SwissProt: P01730 Human





Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

此抗體可識別55KDⅠ型單鏈穿膜糖蛋白。 CD4分子是存在于大多數(shù)輔助/誘導(dǎo)T細(xì)胞表面的59kDa的糖蛋白。正常淋巴組織中CD4的表達(dá)數(shù)量多于CD8,此抗體主要用于標(biāo)記輔助/誘導(dǎo)T細(xì)胞,與CD8單抗聯(lián)合使用對外周血淋巴細(xì)胞分型。 CD4抗原是HLA-II類分子和人類免疫缺陷病毒(HIV)-愛滋病的受體,在35-50%外周血淋巴細(xì)胞-輔助和誘導(dǎo)T細(xì)胞(Th/Ti)和70-80%人胸腺細(xì)胞上表達(dá),在人的單核細(xì)胞表面也有低密度的表達(dá)。 CD4抗原有膜結(jié)合型和可溶性兩種形式。Th/Ti可輔助Ig產(chǎn)生和T細(xì)胞毒T細(xì)胞的作用。
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