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Mouse Anti-CD15/RBITC Conjugated antibody (bsm-33111M-RBITC)
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說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢(xún)價(jià)
產(chǎn)品編號(hào) bsm-33111M-RBITC
英文名稱(chēng) Mouse Anti-CD15/RBITC Conjugated antibody
中文名稱(chēng) 羅丹明(RBITC)標(biāo)記的階段特異性胚胎表面抗原-1/CD15單克隆抗體
別    名 Fut4; SSEA-1; 3-FAL; Alpha (1,3) fucosyltransferase; Alpha 13 fucosyltransferase FucT; EC 2.4.1.; ELAM 1 ligand fucosyltransferase; ELAM ligand fucosyltransferase; ELAM1 ligand fucosyltransferase; ELFT; FCT3A; Fuc TIV; Fucosyltransferase 4 alpha 1 3 fucosyltransferase myeloid specific; Fucosyltransferase 4; FucT IV; FUCTIV; FUT4; Galactoside 3 L fucosyltransferase; Lewis X; LeX; SSEA 1; SSEA1; Stage specific embryonic antigen 1; FUC-TIV.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買(mǎi)        大包裝/詢(xún)價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  細(xì)胞膜受體  
抗體來(lái)源 Mouse
克隆類(lèi)型 Monoclonal
克 隆 號(hào) 8B9
交叉反應(yīng) (predicted: Human, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 58kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CD15
亞    型 IgG
純化方法 affinity purified by Protein G
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq].

Function:
May catalyze alpha-1,3 glycosidic linkages involved in the expression of Lewis X/SSEA-1 and VIM-2 antigens.

Subcellular Location:
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.

Tissue Specificity:
Highest expression in stomach and colon. It is also expressed in the lung, testis, uterus, small intestine and to a lesser extent in spleen, and ovary. Present in trace amounts in brain, thymus, heart, smooth muscle, kidney and bone marrow. Not found in liver, salivary gland and pancreas.

Similarity:
Belongs to the glycosyltransferase 10 family.

Database links:

Entrez Gene: 10690 Human

Entrez Gene: 2526 Human

Entrez Gene: 2527 Human

Entrez Gene: 2528 Human

Entrez Gene: 2529 Human

Omim: 104230 Human

SwissProt: P22083 Human

SwissProt: P51993 Human

SwissProt: Q11128 Human

SwissProt: Q11130 Human

SwissProt: Q9Y231 Human

Unigene: 390420 Human

Unigene: 457 Human

Unigene: 49117 Human

Unigene: 572064 Human

Unigene: 623098 Human

Unigene: 631843 Human

Unigene: 631846 Human

Unigene: 705615 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

CD15(SSEA-1)是胚胎干細(xì)胞表達(dá)胚胎階段特異性抗原的主要SSEA-1蛋白,還包括、SSEA-3、TRA-1-81、TRA-1-60等。CD15主要存在于粒細(xì)胞(包括中性粒細(xì)胞和嗜酸性粒細(xì)胞)以及部分單核細(xì)胞上。它在介導(dǎo)細(xì)胞吞噬細(xì)菌和趨化性方面起重要作用。CD15常表達(dá)于霍奇金氏病中R-S細(xì)胞,尤其是經(jīng)典型霍奇金淋巴瘤中。結(jié)節(jié)硬化型霍奇金淋巴瘤多為CD15陽(yáng)性。CD15抗體是鑒定霍奇金氏病的一個(gè)有效工具。
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