產(chǎn)品編號 | bs-20625R-BF350 |
英文名稱 | Rabbit Anti-OPG/BF350 Conjugated antibody |
中文名稱 | BF350標記的骨保護蛋白/護骨素抗體 |
別 名 | MGC29565; OCIF; OPG; Osteoclastogenesis Inhibitory Factor; TNFRSF 11B; TNFRSF11B; TR 1; TR1; Tumor Necrosis Factor Receptor Superfamily Member 11b; TR11B_HUMAN. |
規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
說 明 書 | 100ul |
研究領(lǐng)域 | 腫瘤 細胞生物 免疫學 信號轉(zhuǎn)導 骨髓細胞 |
抗體來源 | Rabbit |
克隆類型 | Polyclonal |
交叉反應(yīng) | (predicted: Human, Mouse, Rat, Rabbit, ) |
產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 44kDa |
性 狀 | Lyophilized or Liquid |
濃 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human OPG |
亞 型 | IgG |
純化方法 | affinity purified by Protein A |
儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
產(chǎn)品介紹 |
background: Osteoprotegerin (OPG, or osteoclastogenesis inhibitory factor) is a secretory glycoprotein belonging to TNF receptor superfamily. Acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis. Bone homeostasis seems to depend on the local RANKL/OPG ratio. May also play a role in preventing arterial calcification. May act as decoy receptor for TRAIL and protect against apoptosis. TRAIL binding blocks the inhibition of osteoclastogenesis. OPG acts as a soluble factor in the regulation of bone mass and may be beneficial in the treatment of osteoporosis with increased osteoclast activity. OPG consists of 401 amino acids with a molecular weight of 44 kDa as a monomer and 90 kDa as a disulphide-linked dimer. Function: Acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local RANKL/OPG ratio. May also play a role in preventing arterial calcification. May act as decoy receptor for TRAIL and protect against apoptosis. TRAIL binding blocks the inhibition of osteoclastogenesis. Subunit: Homodimer. Subcellular Location: Secreted. Tissue Specificity: Highly expressed in adult lung, heart, kidney, liver, spleen, thymus, prostate, ovary, small intestine, thyroid, lymph node, trachea, adrenal gland, testis, and bone marrow. Detected at very low levels in brain, placenta and skeletal muscle. Highly expressed in fetal kidney, liver and lung. Post-translational modifications: N-glycosylated. Contains sialic acid residues. The N-terminus is blocked. DISEASE: Defects in TNFRSF11B are the cause of juvenile Paget disease (JPD) [MIM:239000]; also known as hyperostosis corticalis deformans juvenilis or hereditary hyperphosphatasia or chronic congenital idiopathic hyperphosphatasia. JPD is a rare autosomal recessive osteopathy that presents in infancy or early childhood. The disorder is characterized by rapidly remodeling woven bone, osteopenia, debilitating fractures, and deformities due to a markedly accelerated rate of bone remodeling throughout the skeleton. Approximately 40 cases of JPD have been reported worldwide. Unless it is treated with drugs that block osteoclast-mediated skeletal resorption, the disease can be fatal. Similarity: Contains 2 death domains. Contains 4 TNFR-Cys repeats. Database links: Entrez Gene: 4982 Human Omim: 602643 Human SwissProt: O00300 Human Unigene: 81791 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 護骨素又稱護骨因子(osteorotegenin,OPG)、骨保護蛋白、破骨細胞生成抑制因子、骨保護素、破骨細胞抑制生成因子(osteoclastogenesis inhibitory factor,OCIF) OPG屬于TNF受體超家族,主要功能是抑制破骨細胞的分化、成熟破骨細胞的骨吸收活性,并誘導其凋亡。 |
1、抗體溶解方法 | |
2、抗體修復方式 | |
3、常用試劑的配制 | |
4、免疫組化操作步驟 | |
5、免疫組化問題解答 | |
6、Western Blotting 操作步驟 | |
7、Western Blotting 問題解答 | |
8、關(guān)于肽鏈的設(shè)計 | |
9、多肽的溶解與保存 | |
10、酶標抗體效價測定程序 | |
| 久99热人妻偷产无码区牛牛直播 | 亚洲无码在线观看高清视频 | 久久国产精品一区二区 | 免费A级毛片无码久久 | 奶好大灬好硬灬好爽在线播放 | 午夜理理伦一级A片无码软件 | 乱码丰满人妻一二三区痴汉电车 | 国产无码精品久久豆腐 | 特级西西大胆WWW147 | 精品丰满熟女少妇一区二区漫画 | 91精品国产综合久久久久久漫画 | 欧美大黑BBBBBBBBB香啊 | 亚洲成人视频在线观看无码 | 亚洲精品国产成人久久Av盗摄 | 人妻野战在线一区三区 | 国产偷窃熟妇毛多水有多 | 免费的黄色视频网站下载在线 | 亚洲AV无码乱码精品国产白浆 | 国产精品妖精久久人妻嫩 | 中文字幕人妻熟女一区二区三区电影 | 摸BBB揉BBB揉BBB视频 | 四川少妇BBBB一区二区 | 真实的国产乱ⅩXXX88 | 99精品国产一区二区 | 四川少妇一级AAAAA片 | 国产一级a毛一级a做免费图片 | 红桃视频免费入口 | 国产激情久久久久久一级A片老师 | 午夜成人电影在线观看 | 北京熟妇槡BBBB槡BBBB一 | 少妇一级婬片免费放下载 | 粉嫩av精色欲人妻精品 | 做暧暧视频高潮一区二区三区 | 精品无码婬片AAAA视频 | 西西4444wwww无码| 亚洲大成色WWW永久网站自慰 | 色乱一区二区三区四区五匹 | 波多野结衣被肉翻猛高潮 | 久久精品www人人爽人人 | 亚欧精品久久人人妻人人爽 |