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Mouse Anti-Cytochrome C/Gold Conjugated antibody (bsm-33193M-Gold)
訂購熱線:400-901-9800
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訂購QQ:  400-901-9800
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說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bsm-33193M-Gold
英文名稱 Mouse Anti-Cytochrome C/Gold Conjugated antibody
中文名稱 膠體金標記的細胞色素C單克隆抗體
別    名 CytC; CYC; CYCS; Cytochrome c somatic; HCS; CYC_HUMAN; Cytochrome c; MSA06; THC4.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領(lǐng)域 腫瘤  心血管  細胞生物  神經(jīng)生物學  細胞凋亡  線粒體  
抗體來源 Mouse
克隆類型 Monoclonal
克 隆 號 6B10
交叉反應 Human, Rat,  (predicted: Mouse, )
產(chǎn)品應用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 14kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 Recombinant human Cytochrome C Protein
亞    型 IgG
純化方法 affinity purified by Protein G
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
Cytochrome C is an electron transporting protein that resides within the intermembrane space of the mitochondria, where it plays a critical role in the process of oxidative phosphorylation and production of cellular ATP. An increasing amount of interest has been directed toward the role which cytocrome C has been demonstrated to play in apoptotic processes. Following exposure to apoptotic stimuli, cytochrome C is rapidly released from the mitochondria into the cytosol, an event which may be required for the completion of apoptosis in some systems. Cytosolic cytochrome C functions in the activation of caspase 3, an ICE family molecule that is a key effector of apoptosis.

Function:
Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.

Subcellular Location:
Mitochondrion intermembrane space. Note=Loosely associated with the inner membrane.

Post-translational modifications:
Binds 1 heme group per subunit.
Phosphorylation at Tyr-49 and Tyr-98 both reduce by half the turnover in the reaction with cytochrome c oxidase, down-regulating mitochondrial respiration.

DISEASE:
Defects in CYCS are the cause of thrombocytopenia type 4 (THC4) [MIM:612004]; also known as autosomal dominant thrombocytopenia type 4. Thrombocytopenia is the presence of relatively few platelets in blood. THC4 is a non-syndromic form of thrombocytopenia. Clinical manifestations of thrombocytopenia are absent or mild. THC4 may be caused by dysregulated platelet formation.

Similarity:
Belongs to the cytochrome c family.

Database links:

Entrez Gene: 54205 Human

Entrez Gene: 13063 Mouse

Entrez Gene: 25309 Rat

Omim: 123970 Human

SwissProt: P99999 Human

SwissProt: P62897 Mouse

SwissProt: P62898 Rat

Unigene: 437060 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

細胞色素C(cytC)是一種電子傳遞鏈蛋白為線粒體呼吸鏈必須的成份之一。在哺乳動物細胞中,如此高度保守性蛋白常分布在線立體內(nèi)膜。
新近研究證明細胞漿中細胞色素C為激活細胞調(diào)亡所必需的因子。在調(diào)亡的過程中,細胞色素C從線立體膜被易位到細胞漿,由細胞色素C激活Caspase-3(CPP32)。
細胞色素C的易位可被過量表達的Bcl-2阻斷。細胞色素B與細胞色素C1和Rieske蛋白相結(jié)合而形成復合物III(也稱細胞色素B-C1復合物)參與細胞呼吸鏈。該蛋白動物種屬間同源性較高;如 :豬、犬、牛、雞、豚鼠等。
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