91精品少妇一区二区三区蜜桃臀,少妇搡BBBB搡BBB搡失恋,BBB片一毛片A片AA少妇,国产成人无码久久久久毛片朴信惠
掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
亚洲AV无码成人精品区国产,国产一区二区三区在线
Rabbit Anti-ERO1L/Cy7 Conjugated antibody (bs-10551R-Cy7)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-10551R-Cy7
英文名稱 Rabbit Anti-ERO1L/Cy7 Conjugated antibody
中文名稱 Cy7標(biāo)記的內(nèi)質(zhì)網(wǎng)氧化物蛋白Ero1-Lα抗體
別    名 Endoplasmic oxidoreductin 1 like protein; Endoplasmic oxidoreductin-1-like protein; ERO1 alpha; ERO1 L; ERO1 Lalpha; ERO1 like protein alpha; ERO1-L; ERO1-L-alpha; ERO1-like (S. cerevisiae); ERO1-like protein alpha; ERO1A; ERO1A_HUMAN; ERO1L; Oxidoreductin 1 Lalpha; Oxidoreductin-1-L-alpha.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 腫瘤  細(xì)胞生物  轉(zhuǎn)運(yùn)蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,  (predicted: Mouse, Rat, Rabbit, )
產(chǎn)品應(yīng)用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 52kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ERO1L
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Ero1-La is an essential oxidoreductase that oxidizes proteins and is required for the folding of immunoglobulins. Ero-1La covalently binds with PDI (protein disulfide-isomerase) and together they produce disulfide bonds between proteins in the endoplasmic reticulum. Ero1-La and SIRT1 regulate adiponectin secretion from adipose tissue. Ero1-La and associated proteins also modulate PPARg (peroxisome proliferator-activated receptor g) and SIRT1 activities. Ero1-La is stimulated by hypoxia, suggesting that it is regulated through the HIF (hypoxia inducible transcrip-tion factor) pathway. Ero1-La is ubiquitously expressed at low levels but expressed at high levels in upper digestive tract and esophagus. Ero1-La may function both as a monomer and a homodimer.

Function:
Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly P4HB/PDI isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on P4HB/PDI to transfer oxidizing equivalent. Associates with ERP44 but not with GRP54, demonstrating that it does not oxidize all PDI related proteins and can discriminate between PDI and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Acts independently of glutathione. May be responsible for a significant proportion of reactive oxygen species (ROS) in the cell, thereby being a source of oxidative stress. Required for the folding of immunoglobulin proteins. Responsible for the release of the unfolded cholera toxin from reduced P4HB/PDI in case of infection by V.cholerae, thereby playing a role in retrotranslocation of the toxin.

Subunit:
Predominantly monomer. May function both as a monomer and a homodimer. Interacts with PDILT

Subcellular Location:
Endoplasmic reticulum membrane. The association with ERP44 is essential for its retention in the endoplasmic reticulum.

Tissue Specificity:
Widely expressed at low level. Expressed at high level in upper digestive tract. Highly expressed in esophagus. Weakly expressed in stomach and duodenum.

Post-translational modifications:
N-glycosylated.
The Cys-94/Cys-99 and Cys-394/Cys-397 disulfide bonds constitute the redox-active center.
The Cys-94/Cys-99 disulfide bond may accept electron from P4HB and funnel them to the active site disulfide Cys-394/Cys-397.

Similarity:
Belongs to the EROs family.

Database links:

Entrez Gene: 30001 Human

Entrez Gene: 50527 Mouse

Entrez Gene: 171562 Rat

Omim: 615435 Human

SwissProt: Q96HE7 Human

SwissProt: Q8R180 Mouse

SwissProt: Q8R4A1 Rat

Unigene: 592304 Human

Unigene: 387108 Mouse

Unigene: 64648 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 m.rvdoil.com 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
农村乱人妻一区二区三区 | 国产 老妇 视频黑人 | 国内成人漫画一二三区 | 国产一级婬片A片AAAA级 2 0 | 午夜精品久久久久久久 | 甘肃WBBBB搡wBBBB | 亚洲在线免费观看 | 久久人妻无码毛片A片麻豆 亚洲乱码精品久久久久.. | 国产精品 日本 欧美 | 国产一区porn在线 | 成人午夜免费福利大片 | 国产性爱少妇性爱无 | 免费无码婬片aaaa | 国产激情二级婬片免费桃 | 亚洲AV无码一区二区三区dv | 国产一级a毛一级a做免费图片 | 国产真实乱婬A片三区高清蜜臀 | 真人免费视频做成A片 | 激情五月天综合网 | 欧美婬片a片aaa毛片直播 | 熟妇人妻中文AV无码 | 白丝女疯狂 喷水自慰爽 | 国产91精品秘 入福利姬 | 东北少妇不戴套直接进入 | 成人做爰黄A片免费视频网站野外 | 欧美老熟妇乱大交XXXXX | 精品少妇人妻av无码中文字幕 | 国产精品久久久久久一级毛片4 | 强奸电影3P日本一二区免费 | 人人看,人人澡,人人人 | 亚洲熟女av一区二区三区 | 国产又粗又长又爽视频 | 精品无码人妻一区二区免费蜜桃 | 久久青草38国产 | 国产精品老熟女视频一区二区 | 国产在线视频一区 | 免费人妻AV无码专区 | 爽爽午国产 浪潮AV性色www | 国产一区二区丝袜高跟 | 成人午夜电影在线观看 | 91午夜夜伦鲁鲁片无码影视 |