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Rabbit Anti-FIZ1/PE Conjugated antibody (bs-13174R-PE)
訂購熱線:400-901-9800
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訂購QQ:  400-901-9800
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-13174R-PE
英文名稱 Rabbit Anti-FIZ1/PE Conjugated antibody
中文名稱 PE標記的鋅指蛋白798抗體
別    名 FLJ00416; FLJ14768; FLT3 interacting zinc finger 1; Flt3 interacting zinc finger protein 1; Zinc finger protein 798; ZNF798; FIZ1_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 細胞生物  神經(jīng)生物學  轉(zhuǎn)錄調(diào)節(jié)因子  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse,  (predicted: Rat, Pig, Cow, Sheep, )
產(chǎn)品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 52kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human FIZ1/ZNF798
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. FIZ1 (FLT3-interacting zinc finger 1), also known as ZNF798 (zinc finger protein 798), is a 496 amino acid zinc-finger protein that contains eleven C2H2-type zinc fingers. Localized to both the cytoplasm and the nucleus and expressed in a wide variety of tissues, FIZ1 is thought to repress the function of Nrl (neural retina leucine zipper) in photoreceptors, possibly regulating the expression of rod-specific genes. Additionally, FIZ1 interacts with the receptor-related tyrosine kinase Flt-3/Flk-2 and, via this interaction, may be involved in the regulation of lymphoid and hematopoietc cells.

Function:
FIZ1 is a zinc finger protein, which interacts with a receptor tyrosine kinase involved in the regulation of hematopoietic and lymphoid cells. It also interacts with a transcription factor that regulates the expression of rod-specific genes in retina.

Subunit:
Interacts with FLT3 cytoplasmic catalytic domain, following receptor stimulation, in a kinase-independent manner. Does not interact with other structurally related receptor tyrosine kinases, including KIT, CSF1R and PDGFR. Interacts with NRL (By similarity).

Subcellular Location:
Cytoplasm. Nucleus.

Tissue Specificity:
Widely expressed.

Similarity:
Contains 11 C2H2-type zinc fingers.

Database links:

Entrez Gene: 84922 Human

Omim: 609133 Human

SwissProt: Q96SL8 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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