91精品少妇一区二区三区蜜桃臀,少妇搡BBBB搡BBB搡失恋,BBB片一毛片A片AA少妇,国产成人无码久久久久毛片朴信惠
掃碼關(guān)注公眾號(hào)           掃碼咨詢(xún)技術(shù)支持           掃碼咨詢(xún)技術(shù)服務(wù)
  
客服熱線(xiàn):400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
精品国产鲁一鲁一区二区真希友田 ,国产一级婬片A片AAA樱花
Rabbit Anti-phospho-beta 2 Adrenergic Receptor (Ser355 + Ser356)/BF350 Conjugated antibody (bs-12979R-BF350)
訂購(gòu)熱線(xiàn):400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢(xún)價(jià)
產(chǎn)品編號(hào) bs-12979R-BF350
英文名稱(chēng) Rabbit Anti-phospho-beta 2 Adrenergic Receptor (Ser355 + Ser356)/BF350 Conjugated antibody
中文名稱(chēng) BF350標(biāo)記的磷酸化腎上腺素能受體β2/β2-AR抗體
別    名 beta 2 Adrenergic Receptor (phospho S355 + S356); beta 2 Adrenergic Receptor (phospho S346); p-beta 2 Adrenergic Receptor (phospho S346); β2-adrenergic receptor; beta 2 Adrenergic Receptor; ADRB2; ADRB2R; ADRBR; ADRB2_HUMAN; Adrenergic beta 2 receptor surface; B2AR; BAR; beta 2 adrenoceptor; Beta 2 adrenoreceptor; BETA2AR; Catecholamine receptor; beta2-adrenergic receptor.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買(mǎi)        大包裝/詢(xún)價(jià)
說(shuō) 明 書(shū) 100ul  
產(chǎn)品類(lèi)型 磷酸化抗體 
研究領(lǐng)域 腫瘤  細(xì)胞生物  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞膜受體  細(xì)胞膜蛋白  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng) Human, Mouse,  (predicted: Rat, Rabbit, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 46kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human beta 2 Adrenergic Receptor around the phosphorylation site of Ser355 + Ser356
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Beta 2 Adrenergic Receptor is a member of the G protein coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L type calcium channel Ca(V)1.2. This receptor channel complex also contains a G protein, an adenylyl cyclase, cAMP dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein coupled receptor. This gene contains no introns in either its coding or untranslated sequences. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. Expression of the beta 2 Adrenergic Receptor has been reported in adipose, blood, brain, heart, lung, nose, pancreas, skeletal muscle, skin, and vessel.

Function:
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.

Subunit:
Binds SLC9A3R1 and GPRASP1. Interacts with ARRB1 and ARRB2. Interacts with SRC, USP20 and USP33. Interacts with VHL; the interaction, which is increased on hydroxylation of ADRB2, ubiquitinates ADRB2 leading to its degradation. Interacts with EGLN3; the interaction hydroxylates ADRB2 facilitating VHL-E3 ligase-mediated ubiquitination.

Subcellular Location:
Cell membrane; Multi-pass membrane protein. Note=Colocalizes with VHL at the cell membrane.

Post-translational modifications:
Palmitoylated; may reduce accessibility of Ser-345 and Ser-346 by anchoring Cys-341 to the plasma membrane. Agonist stimulation promotes depalmitoylation and further allows Ser-345 and Ser-346 phosphorylation.
Phosphorylated by PKA and BARK upon agonist stimulation, which mediates homologous desensitization of the receptor. PKA-mediated phosphorylation seems to facilitate phosphorylation by BARK.
Phosphorylation of Tyr-141 is induced by insulin and leads to supersensitization of the receptor.
Polyubiquitinated. Agonist-induced ubiquitination leads to sort internalized receptors to the lysosomes for degradation. Deubiquitination by USP20 and USP33, leads to ADRB2 recycling and resensitization after prolonged agonist stimulation. USP20 and USP33 are constitutively associated and are dissociated immediately after agonist stimulation. Ubiquitination by the VHL-E3 ligase complex is oxygen-dependent.
Hydroxylation by EGLN3 occurs only under normoxia and increases the interaction with VHL and the subsequent ubiquitination and degradation of ADRB2.

Similarity:
Belongs to the G-protein coupled receptor 1 family.
Adrenergic receptor subfamily. ADRB2 sub-subfamily.

Database links:

Entrez Gene: 154 Human

Entrez Gene: 11555 Mouse

Entrez Gene: 24176 Rat

Omim: 109690 Human

SwissProt: P07550 Human

SwissProt: P18762 Mouse

SwissProt: P10608 Rat

Unigene: 2551 Human

Unigene: 5598 Mouse

Unigene: 10206 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 m.rvdoil.com 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書(shū)編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書(shū)編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
精品无码一区二区在线蜜桃 | 一级特黄妇女高潮视的特点 | 无码人妻精品一区二区蜜桃漫画 | 亚洲91综合精品 | 精品成人无码一区二区久 | 色欲av无码一区二区人妻 | aaa久久视频在线播放 | 美女脱光黄色裸体网站 | 搡BBBB搡BBB搡五十粉嫩 | 亚洲视频免费在线观看 | 狠狠躁日日躁夜夜躁A片视频小说 | 国产精品羞羞无码久久久莉榴花 | 91久久久无码国产一区二区蜜臀 | 中文字幕免费观看 | 又粗又大又黄视频 | 小向美奈子乳巨码BD播放 | 亚洲AⅤ无码一区二区波多野按摩 | 特级做a爰片毛片免费69 | 老妇裸体性激交老太视频 | 人妻少妇91果冻传媒麻豆 | 亚洲AV无码秘 蜜桃永瀬ゆい | 亚洲AⅤ深喉囗交一区二区 91嫖妓丰满少妇300元 | 国产综合精品久久久久成人AV | 国产人成精品一区二区三 | 久久99深爱久久99精品 | 91.www在线观看 | 日本三级片免费看 | 少妇激情偷人爽爽91嫩草 | 狼友91精品一区二区三区 | 人人妻人人爱人人做人人爽性色AV | 精品成人无码久久久久久 | 粉嫩av浪潮av色欲aV | 西西444WWW无码视频男男 | 18禁网站禁片免费观看 | 公侵犯人妻HD中文字幕 | 人体窝窝7777777粗大野 | 成人交性视频免费看 | 国产丝袜人妻日本口交护士 | 午夜福利视频91久久久 | 国产免费观看高清完整版在线观看 | 91人妻人人澡人人爽 |