產品編號 | bs-6026R-PE-Cy5 |
英文名稱 | Rabbit Anti-TSLC1/PE-Cy5 Conjugated antibody |
中文名稱 | PE-Cy5標記的細胞粘附分子1抗體 |
別 名 | CADM1; BL2; Cadm1; CADM1_HUMAN; Cell adhesion molecule 1; IGSF4A; Immunoglobulin Superfamily Member 4; NECL-2; NECL2; Nectin like 2; Nectin-like protein 2; RA175; SgIGSF; Spermatogenic immunoglobulin superfamily; ST17; sTSLC 1; Synaptic cell Adhesion Molecule; SynCAM; SynCAM1; TSLC-1; TSLC1; Tumor Suppressor in Lung Cancer 1. |
規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
說 明 書 | 100ul |
研究領域 | 免疫學 神經生物學 信號轉導 細胞粘附分子 |
抗體來源 | Rabbit |
克隆類型 | Polyclonal |
交叉反應 | Human, Rat, (predicted: Mouse, Dog, Pig, Cow, Horse, Rabbit, ) |
產品應用 | Flow-Cyt=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 44kDa |
性 狀 | Lyophilized or Liquid |
濃 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human CADM1. |
亞 型 | IgG |
純化方法 | affinity purified by Protein A |
儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
產品介紹 |
background: Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. May act as a synaptic cell adhesion molecule that drives synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa. Function: Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. May act as a synaptic cell adhesion molecule that drives synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa. Subunit: Homodimer. Interacts with CRTAM and EPB41L3/DAL1. The interaction with EPB41L3/DAL1 may act to anchor CADM1 to the actin cytoskeleton. Interacts via its C-terminus with the PDZ domain of MPP3 and the PDZ domain of MPP6. Subcellular Location: Cell membrane; Single-pass type I membrane protein. Note=Associates with perinuclear and plasma membranes in vivo. Localized to the basolateral plasma membrane of epithelial cells in gall bladder. Tissue Specificity: Highly expressed in colon, kidney, prostate, intestine and activated lymphocytes. Expressed at much higher levels in the renal cell cancers than in surrounding normal kidney tissue. Moderately expressed in pancreas, ovary and testis. DISEASE: Defects in CA12 are the cause of hyperchlorhidrosis isolated (HCHLH) [MIM:143860]. HCHLH is a disorder characterized by excessive sweating and increased sweat chloride levels. Affected individuals suffer from episodes of hyponatremic dehydration and report increased amounts of visible salt precipitates in sweat. Similarity: Belongs to the nectin family. Contains 2 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 Ig-like V-type (immunoglobulin-like) domain. Database links: Entrez Gene: 23705 Human Entrez Gene: 54725 Mouse Omim: 605686 Human SwissProt: Q9BY67 Human SwissProt: Q8R5M8 Mouse Unigene: 370510 Human Unigene: 234832 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
1、抗體溶解方法 | |
2、抗體修復方式 | |
3、常用試劑的配制 | |
4、免疫組化操作步驟 | |
5、免疫組化問題解答 | |
6、Western Blotting 操作步驟 | |
7、Western Blotting 問題解答 | |
8、關于肽鏈的設計 | |
9、多肽的溶解與保存 | |
10、酶標抗體效價測定程序 | |
| 国产强伦轩免费视频在线 | 国产美女美乳奶头粉嫩在线观看 | 91人人澡人人射人人添 | 亚洲国产精品二二三三区 | 国产在线无码黑桃视频 | 江苏妇搡BBBB搡BBBB | 熟女人妻精品一二三四 | 黄色无码视频免费观看 | 处破初破苞一区二区三区在线播放 | 午夜久久人妻一级内射 | 福利姬视频在线观看 | 蜜桃Av久久精品人人槡 | 欧美性爱XXXX黑人XYX性爽 | 国产村偷农村妇女免费视频 | 国产熟妇搡BBBB搡BBBB | 黄色视频网站在线观看推荐 | 艹b喷水捆绑在线观看 | 免费黄色视频网站免费在线观看 | 无码免费人妻A片AAA毛片西瓜 | 极品媚黑黑人正在播放 | 黄片视频免费在线观看 | 黄色视频免费看完整答版不卡一区二区 | 一本一道久久综合狠狠躁牛牛影视 | 免费网站在线观看禁18进入 | 黄片免费在线观看视频 | 欧美喷潮喷水失禁合集 | 91嫖妓站街妓女按摩店 | 51精品丝袜国产高跟在线 | 91嫩草精品少妇91嫩草影视剧 | 26uuu精品一区二区三区 | 成人A片产无码免费视频奶头麻豆 | 久久久国产色情无码A片爆乳直播 | 国产一级a毛一级a看免费观看 | 国产一级姪片A片高潮 | 国产suv精品一区二区6 | 欧美无砖砖区免费 | 国产做爰XXXⅩ高潮窒息情欲 | 做暧暧视频高潮一区二区三区 | 爽灬爽灬爽灬毛及A片小说 日韩av无码高清一区免费 | 男人和女人差差啊啊啊啊啊 |