| 產(chǎn)品編號 | bs-1197R-BF488 |
| 英文名稱 | Rabbit Anti-TLR5/BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的Toll樣受體5抗體 |
| 別 名 | toll-like receptor 5; FLJ10052; MGC126430; MGC126431; TIL 3; TIL3; TLR 5; Toll like receptor 5; Toll like receptor 5 precursor; Toll/interleukin 1 receptor like protein 3;CD285; TLR5_MOUSE. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 腫瘤 免疫學(xué) 信號轉(zhuǎn)導(dǎo) 細胞膜受體 細菌及病毒 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human, Mouse, (predicted: Rat, ) |
| 產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 95kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from mouse TLR5 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: The Toll like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules and could constitute an important and unrecognized component of innate immunity in humans. The TRL family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. TLRs characterized so far activate the MyD88/interleukin 1 receptor-associated kinase (IRAK) signaling pathway. Toll-like receptor 5 (TLR5) expression is upregulated following exposure to bacteria or to the TLR5 agonist, flagellin. Gram-negative bacteria, stimulate monocyte/macrophage cells in a TLR5-specific, CD14-independent manner. The TLR5 receptor thus appears to be the principal means by which the innate immune system recognizes flagellated bacterial pathogens. Function: Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). Subunit: Homodimer both in the absence and presence of ligand. Binds MYD88 via their respective TIR domains (By similarity). Subcellular Location: Membrane; Single-pass type I membrane protein (By similarity). Tissue Specificity: Highly expressed in liver. Detected in lung and at very low levels in most other tissues. Post-translational modifications: Phosphorylated at Tyr-799 upon flagellin binding; required for signaling (By similarity). Similarity: Belongs to the Toll-like receptor family. Contains 16 LRR (leucine-rich) repeats. Contains 1 TIR domain. Database links: Entrez Gene: 7100 Human Entrez Gene: 53791 Mouse Omim: 603031 Human SwissProt: O60602 Human SwissProt: Q9JLF7 Mouse Unigene: 604542 Human Unigene: 116894 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Toll樣受體5可在單核細胞、未成熟樹突狀細胞及上皮細胞表達 ,可能是一種參與免疫應(yīng)答的受體 ,其具體作用尚不清楚。 TLR5可辨認鞭毛蛋白(fla-gellin),此種蛋白可組成鞭毛,與細菌泳動有關(guān). |
