產(chǎn)品編號(hào) | bs-5381R-PE-Cy3 |
英文名稱 | Rabbit Anti-Phospho-NMDAR2B (Tyr1336)/PE-Cy3 Conjugated antibody |
中文名稱 | PE-Cy3標(biāo)記的磷酸化谷氨酸受體2B抗體 |
別 名 | NMDAR2B (phospho Y1336); p-NMDAR2B (phospho Y1336); NMDAR2B (Phospho-Tyr1336); NMDAR2B (Phospho-Y1336); p-NMDAR2B (Tyr1336); p-NMDAR2B (Y1336); AW490526; Glutamate [NMDA] receptor subunit epsilon 2; Glutamate [NMDA] receptor subunit epsilon-2; Glutamate Receptor Ionotropic N Methyl D Aspartate 2B; Glutamate Receptor Ionotropic N Methyl D Aspartate subunit 2B; Glutamate receptor ionotropic NMDA2B; Glutamate receptor subunit epsilon 2; Glutamate receptor, ionotropic, NMDA2B (epsilon 2); GRIN 2B; GRIN2B; hNR 3; hNR3; MGC142178; MGC142180; N methyl D asparate receptor channel subunit epsilon 2; N METHYL D ASPARTATE RECEPTOR CHANNEL SUBUNIT EPSILON 2; N methyl D aspartate receptor subtype 2B; N methyl D aspartate receptor subunit 2B; N methyl D aspartate receptor subunit 3; N-methyl D-aspartate receptor subtype 2B; N-methyl-D-aspartate receptor subunit 3; NMDA NR2B; NMDA R2B; Nmdar2b; NMDE2; NMDE2_HUMAN; NME2; NR2B; NR3. |
規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買 大包裝/詢價(jià) |
說 明 書 | 100ul |
產(chǎn)品類型 | 磷酸化抗體 |
研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) 神經(jīng)生物學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 細(xì)胞膜受體 |
抗體來源 | Rabbit |
克隆類型 | Polyclonal |
交叉反應(yīng) | Rat, (predicted: Human, Mouse, Chicken, Dog, Pig, Cow, Horse, Rabbit, ) |
產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 164kDa |
性 狀 | Lyophilized or Liquid |
濃 度 | 1mg/ml |
免 疫 原 | KLH conjugated Synthesised phosphopeptide derived from mouse NMDAR2B around the phosphorylation site of Tyr1336 |
亞 型 | IgG |
純化方法 | affinity purified by Protein A |
儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
產(chǎn)品介紹 |
background: N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain. [provided by RefSeq, Jul 2008]. Function: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity). Subunit: Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Found in a complex with GRIN1 and GRIN3B. Found in a complex with GRIN1, GRIN3A and PPP2CB. Interacts with PDZ domains of INADL and DLG4. Interacts with HIP1 and NETO1 (By similarity). Interacts with MAGI3. Interacts with DAPK1 (By similarity). Subcellular Location: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Tissue Specificity: Primarily found in the fronto-parieto-temporal cortex and hippocampus pyramidal cells, lower expression in the basal ganglia. Post-translational modifications: Phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity (By similarity). DISEASE: Defects in GRIN2B are the cause of mental retardation autosomal dominant type 6 (MRD6) [MIM:613970]. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Note=Chromosomal aberrations involving GRIN2B have been found in patients with mental retardation. Translocations t(9;12)(p23;p13.1) and t(10;12)(q21.1;p13.1) with a common breakpoint in 12p13.1. Similarity: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2B/GRIN2B subfamily. Database links: Entrez Gene: 2904 Human Entrez Gene: 14812 Mouse Omim: 138252 Human SwissProt: Q13224 Human SwissProt: Q01097 Mouse Unigene: 654430 Human Unigene: 436649 Mouse Unigene: 9711 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 谷氨酸受體(NR2B)是脊椎動(dòng)物中樞神經(jīng)系統(tǒng)興奮型神經(jīng)傳遞的主要介質(zhì)。在突觸可塑性極大腦學(xué)習(xí)及記憶功能方面起關(guān)鍵作用。 |
| 国产精品美女www爽爽爽视频 | 日韩在线视频网站 | 亚洲乱熟乱熟女一区二区 | 色婷婷一二三精品A片 | 国产人成一区二区三区影院 | 国产精品三级久久久人妻 | 久久久无码精品欧美传媒 | 丰满又紧又爽又丰满视频 | 西西美女裸体视频久久 | 韩国一级婬片A片AAA免费下载 | 国产成人无码精品久久久久 | 国产视频久久久999 国产白洁视频免费观看 | 一级丰满老熟女毛片AV | 青青草玖玖爱在线视频 | 无套内射无矿码免费看黄 | 成人网站在线进入爽爽爽 | 亚洲无码在线播放 | 亚洲日韩在线观看视频 | 国产无套丰满白嫩对白 | 苍井空一级婬片A片AAA片动漫 | 一级婬片试看60秒 | 麻豆传媒在线观看国产 | 国产成人精品一区二区波多野结衣 | 成人网站在线免费播放 | 亚洲精品网站3D动漫之医院 | 久久Av一区二区三区杨思敏 | 成人A片产无码免费视频奶头麻豆 | 日本不卡在线观看 | 韩国无码一区二区 | 国产成人精欧美黄色三级片精品 | 精品高潮呻吟久久av | 国产成人精品无码 | 口爆吞精在线视频国产 | 自慰 免费网站com | 日本免费在线观看视频 | 好爽好大久久久级婬片毛片 | 亲孑伦视频一区二区三区 | 日韩人妻中文字幕 | 激情婬乱A片AAA毛片97 | 国产裸体无遮挡永久观看 |