產(chǎn)品編號(hào) | bs-5181R-PE-Cy7 |
英文名稱 | Rabbit Anti-phospho-AXL (Tyr698+Tyr702+Tyr703)/PE-Cy7 Conjugated antibody |
中文名稱 | PE-Cy7標(biāo)記的磷酸化粘附相關(guān)激酶抗體 |
別 名 | Adhesion related kinase; AI323647; Ark; Axl; AXL oncogene; AXL receptor tyrosine kinase; AXL transforming gene; AXL transforming sequence/gene; EC 2.7.10.1; JTK11; Oncogene AXL; Tyro7; Tyrosine protein kinase receptor UFO; Tyrosine-protein kinase receptor UFO; UFO; UFO_HUMAN. |
規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買(mǎi) 大包裝/詢價(jià) |
說(shuō) 明 書(shū) | 100ul |
產(chǎn)品類(lèi)型 | 磷酸化抗體 |
研究領(lǐng)域 | 腫瘤 細(xì)胞生物 免疫學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 細(xì)胞周期蛋白 激酶和磷酸酶 細(xì)胞膜受體 細(xì)胞類(lèi)型標(biāo)志物 |
抗體來(lái)源 | Rabbit |
克隆類(lèi)型 | Polyclonal |
交叉反應(yīng) | Human, (predicted: Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, ) |
產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 95kDa |
性 狀 | Lyophilized or Liquid |
濃 度 | 1mg/ml |
免 疫 原 | KLH conjugated Synthesised phosphopeptide derived from human AXL around the phosphorylation site of Tyr698+Tyr702+Tyr703 |
亞 型 | IgG |
純化方法 | affinity purified by Protein A |
儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
產(chǎn)品介紹 |
background: The protein encoded by this gene is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, the Axl protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors such as vitamin K dependent protein growth arrest specific gene 6. It is involved in the stimulation of cell proliferation. This receptor can also mediate cell aggregation by homophilic binding. Axl is a chronic myelogenous leukemia associated oncogene and also associated with colon cancer and melanoma.The Axl gene is evolutionarily conserved between vertebrate species. This gene has two different alternatively spliced transcript variants (AXL1 and AXL2). Function: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TENC1. Recruitment of GRB2 and phosphatidylinositol-3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. In case of filovirus infection, seems to function as a cell entry factor. Subunit: Heterodimer and heterotetramer with ligand GAS6. Interacts with CBL, GRB2, LCK, NCK2, PIK3R1, PIK3R2, PIK3R3, PLCG1, SOCS1 and TENC1. Part a complex including AXL, TNK2 and GRB2, in which GRB2 promotes AXL recruitment by TNK2. Subcellular Location: Cell membrane; Single-pass type I membrane protein. Tissue Specificity: Highly expressed in metastatic colon tumors. Expressed in primary colon tumors. Weakly expressed in normal colon tissue. Post-translational modifications: Phosphorylated at tyrosine residues by autocatalysis, which activates kinase activity. DISEASE: Note=AXL and its ligand GAS6 are highly expressed in thyroid carcinoma tissues, and might thus be involved in thiroid tumorigenesis. Overexpression of AXL and its ligand was also detected in many other cancers such as myeloptoliferative disorders, prostatic carcinoma cells, or breast cancer. Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily. Contains 2 fibronectin type-III domains. Contains 2 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 protein kinase domain. Database links: Entrez Gene: 558 Human Omim: 109135 Human SwissProt: P30530 Human Unigene: 590970 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 国产av放荡人妇一区二区 | 91久久久无码国产一区二区蜜臀 | 91茄子短视频在线观看 | 中文在线字幕免费观看 | 美女搡BBB又爽又猛又黄www | 五十路老熟妇一区二区三区 | 一级女婬片A片AAAA片 | 国产视频无码在线观看 | 脫衣舞一区二区三区 | 一本色道久久99精品综合蜜臀 | 欧一美一交一配一交一交一视频 | 91人妻边做边打电话AⅤ | 日韩无码免费观看视频 | 囯产精品久久久久久久 | 四虎影成人精品A片 | 国产精品粉嫩+91在线++B | 一本色道综合人妻无码 | 日本AAA片毛片免费观蜜桃 | 鲁大师手机在线日韩 | 色情婷婷国产在线视频 | 欧美69久成人做爰视频 | 色婷婷AV一区二区三区大白胸 | 污网站高清无码在线观看 | 亚洲精品久久一区二区三区蜜桃臀 | 亚洲无码精品一区二区 | 99精品丰满人妻无码 | 日韩黄色电影在线观看 | 国产又粗又猛视频免费h | 精品无码一区二区在线蜜桃 | 蜜桃臀aⅴ精品一区二区三区 | 鲁大师成人A片免费高清 | 免费看一级一级人妻片 | 1000部免费A片视频 | 3d动漫啪啪一区二区免费 | 国产精品国产三级国产专区53 | 国产黄色视频在线观看 | 午夜成人免费黄色电影 | 成人AV中文解说水果派 | 国产亚洲一区二区精品 | 性感jk白丝喷水在线免费观看 |