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Rabbit Anti-PAX9/Cy7 Conjugated antibody (bs-1102R-Cy7)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-1102R-Cy7
英文名稱 Rabbit Anti-PAX9/Cy7 Conjugated antibody
中文名稱 Cy7標記的配對盒基因9抗體
別    名 Paired box 9; Paired box gene 9; Paired box homeotic gene 9; Paired box protein 9; Paired box protein Pax 9; Paired box protein Pax9; Paired domain gene 9; PAX 9; PAX9_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  信號轉導  細胞凋亡  轉錄調節(jié)因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, 
產(chǎn)品應用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 36kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PAX9
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
PAX9 is a member of the paired box (PAX) family of transcription factors. Proteins in this family typically contain a paired box domain, a paired type homeodomain and an octapeptide sequence. They are important during fetal development and have also been implicated in cancer growth.
The exact role of PAX9 is unclear, but it is thought to be involved in development of various organs, skeletal tissue and stratified squamous epithelia. Mutations in PAX9 have also been implicated in oligodontia, a type of tooth agenesis which is a common developmental anomoly in humans.

Function:
Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs (By similarity).

Subunit:
Interacts with KDM5B.

Subcellular Location:
Nucleus.

DISEASE:
ooth agenesis selective 3 (STHAG3) [MIM:604625]: A form of selective tooth agenesis, a common anomaly characterized by the congenital absence of one or more teeth. Selective tooth agenesis without associated systemic disorders has sometimes been divided into 2 types: oligodontia, defined as agenesis of 6 or more permanent teeth, and hypodontia, defined as agenesis of less than 6 teeth. The number in both cases does not include absence of third molars (wisdom teeth). Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Contains 1 paired domain.

Database links:

Entrez Gene: 5083 Human

Entrez Gene: 18511 Mouse

Entrez Gene: 362741 Rat

Omim: 167416 Human

SwissProt: P55771 Human

SwissProt: P47242 Mouse

SwissProt: Q2L4T2 Rat

Unigene: 132576 Human

Unigene: 609574 Human

Unigene: 5035 Mouse

Unigene: 82416 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

同源結構域蛋白(Homeodomain Proteins)
PAX9屬于轉錄抑制因子PAXs的一種。在胚胎發(fā)育和腫瘤生長中起關鍵作用。其突變和某些腫瘤的發(fā)病有關。<
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