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Rabbit Anti-FNDC5/BF488 Conjugated antibody (bs-8486R-BF488)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-8486R-BF488
英文名稱 Rabbit Anti-FNDC5/BF488 Conjugated antibody
中文名稱 BF488標記的Ⅲ型纖維連接蛋白域蛋白2/5抗體
別    名 FNDC5; Fibronectin type III domain containing 5; Fibronectin type III domain-containing protein 5; Fibronectin type III repeat containing protein 2; Fibronectin type III repeat-containing protein 2; FNDC 5; Fndc5; FNDC5_HUMAN; FRCP2; Irisin.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  免疫學  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse,  (predicted: Rat, Chicken, Dog, Rabbit, )
產(chǎn)品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 12/20kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human FNDC5 Irisin
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes a secreted protein that is released from muscle cells during exercise. The encoded protein may participate in the development of brown fat. Translation of the precursor protein initiates at a non-AUG start codon at a position that is conserved as an AUG start codon in other organisms. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013].

Function:
Irisin: mediates beneficial effects of muscular exercise. Induces browning of white adipose tissue by stimulating UCP1 expression, at least in part, via the nuclear receptor PPARA (By similarity).

Subcellular Location:
Cell membrane; Single-pass type I membrane protein. Peroxisome membrane; Single-pass type I membrane protein (By similarity). Note=Imported in peroxisomes through the PEX5 receptor pathway (By similarity).
Irisin: Secreted. Note=Detected in the blood of individuals subjected to endurance exercise.

Post-translational modifications:
The extracellular domain is cleaved and released from the cell membrane.
N-Glycosylated.

Similarity:
Contains 1 fibronectin type-III domain.

Database links:

Entrez Gene: 252995 Human

Entrez Gene: 384061 Mouse

Entrez Gene: 260327 Rat

Omim: 611906 Human

SwissProt: Q8NAU1 Human

SwissProt: Q8K4Z2 Mouse

SwissProt: Q8K3V5 Rat

Unigene: 524234 Human

Unigene: 44075 Mouse

Unigene: 18757 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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