產(chǎn)品編號(hào) | bs-0122R-PE-Cy5.5 |
英文名稱 | Rabbit Anti-Estrogen Receptor alpha/PE-Cy5.5 Conjugated antibody |
中文名稱 | PE-Cy5.5標(biāo)記的雌激素受體α抗體 |
別 名 | Estradiol receptor; Estrogen receptor alpha; Estradiol Receptor-alpha; Estrogen Receptor 1; Atherosclerosis, susceptibility to, included; DKFZp686N23123; ER Alpha; ER; ER-alpha; ERalpha; ER[a]; Era; ESR; ESR1; ESR1_HUMAN; ESR2; ESRA; Estr; Estrogen receptor 1 (alpha); Estrogen resistance, included; HDL cholesterol, augmented response of, to hormone replacement, included; Myocardial infarction, susceptibility to, included; NR3A1; Nuclear receptor subfamily 3 group A member 1; OTTHUMP00000017718; OTTHUMP00000017719; RNESTROR. |
規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買 大包裝/詢價(jià) |
說 明 書 | 100ul |
研究領(lǐng)域 | 腫瘤 免疫學(xué) 生長(zhǎng)因子和激素 |
抗體來源 | Rabbit |
克隆類型 | Polyclonal |
交叉反應(yīng) | Human, (predicted: Mouse, Rat, Dog, Cow, Rabbit, ) |
產(chǎn)品應(yīng)用 |
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 67kDa |
性 狀 | Lyophilized or Liquid |
濃 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from the middle of human Estrogen Receptor alpha |
亞 型 | IgG |
純化方法 | affinity purified by Protein A |
儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
產(chǎn)品介紹 |
background: Estrogen and progesterone receptor are members of a family of transcription factors that are regulated by the binding of their cognate ligands. The interaction of hormone-bound estrogen receptors with estrogen responsive elements(EREs) alters transcription of ERE-containing genes. The carboxy terminal region of the estrgen receptor contains the ligand binding domain, the amino terminus serves as the transactivation domain, and the DNA binding domain is centrally located. Two forms of estrogen receptor have been identified, ER Alpha and ER Beta. ER Alpha and ER Beta have been shown to be differentially activated by various ligands. The biological response to progesterone is mediated by two distinct forms of the human progesterone receptor (hPR-A and hPR-B), which arise from alternative splicing. In most cells, hPR-B functions as a transcriptional activator of progesterone-responsive gene, whereas hPR-A function as a transcriptional inhibitor of all steroid hormone receptors. Function: Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Subunit: Interacts with SLC30A9 (By similarity). Binds DNA as a homodimer. Can form a heterodimer with ESR2. Interacts with NCOA3, NCOA5 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts with NCOA7 in a ligand-inducible manner. Interacts with PHB2, PELP1 and UBE1C. Interacts with AKAP13. Interacts with CUEDC2. Interacts with KDM5A. Interacts with SMARD1. Interacts with HEXIM1 and MAP1S. Interacts with PBXIP1. Interaction with MUC1 is stimulated by 7 beta-estradiol (E2) and enhances ERS1-mediated transcription. Interacts with DNTTIP2, FAM120B and UIMC1. Interacts with isoform 4 of TXNRD1. Interacts with MLL2. Interacts with ATAD2 and this interaction is enhanced by estradiol. Subcellular Location: Nucleus. Post-translational modifications: Phosphorylated by cyclin A/CDK2. Phosphorylation probably enhances transcriptional activity. Glycosylated; contains N-acetylglucosamine, probably O-linked. Similarity: Belongs to the nuclear hormone receptor family. NR3 subfamily. Contains 1 nuclear receptor DNA-binding domain. Database links: Entrez Gene: 2099 Human Entrez Gene: 13982 Mouse Omim: 133430 Human SwissProt: P03372 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 類固醇受體(Steroid Receptors) 雌激素受體ER-α(Estrogen Receptor-α, ERα)是一類位于細(xì)胞表面或細(xì)胞內(nèi)的特異性蛋白質(zhì)。 某些特異的雌激素、雌激素類似物、衍生物、拮抗劑或阻斷劑與它結(jié)合后可引發(fā)或阻斷受體蛋白質(zhì)的轉(zhuǎn)化作用。并將雌激素-受體復(fù)合物從細(xì)胞質(zhì)再定位進(jìn)入細(xì)胞核以啟動(dòng)蛋白質(zhì)的生物合成。 |
| 亚洲人午夜射精精品日韩 | 岳胥乱一区二区三区视频 | 欧美日韩一区在线 | 日韩精品无码人妻第一页 | 国产一级a毛一级a看免费视频野外 | 久久久 成人网站免费观看 99热成人精品热久久66 | 亚洲+小说+欧美+激情+另类 | 茄子视频成人一区二区 | 色婷婷一区二区红桃 | 国产三级片最新专区 | 国产午夜精品一区二区三区嫩A | 国产又大又粗又硬视频 | 91精品国偷拍自产在线观看 | 国产人妻 9 9精品无码一区李宗瑞 | 免费无码婬片AAAA在线观看 | 凹凸熟女白浆精品国产91 | 景音先锋日韩欧美制服亚洲 | 亚洲一区二区精品 | 少妇高潮免费看一级A片精东影视 | 婷婷五月婷婷一区二区三区久久久 | 欧美激情午夜精品久久久久久久久 | 精品无码一区二区三区在线朝桐光 | 国产一区二区不卡 | 中文字幕无乱码人妻丝袜 | 一级毛片久久久久久久女人18 | 又黄又爽又无遮挡 | www.国产精品.com | 波多野结衣被狂揉到高潮 | 国产毛片乡下农村妇女BD | 91在线无码精品秘 软件网站 | 人人妻人人玩人人澡人人爽 | 鸥美AV鲁鲁一区二区 | 天天草草草99991 | 在线观看免费无码视频 | 久久婷婷婬片A片AAA | 日本亲近相姦中文字幕特级毛片 | 欧美精品人妻一区二区三区大一片 | 中文在线字幕免费观看 | 91AV一区二区三区 | 蜜桃AV鲁一鲁一鲁一鲁俄罗斯的 |