產(chǎn)品編號(hào) | bs-3093R-Cy5.5 |
英文名稱(chēng) | Rabbit Anti-Phospho-cdc25A (Thr507)/Cy5.5 Conjugated antibody |
中文名稱(chēng) | Cy5.5標(biāo)記的磷酸化細(xì)胞分裂周期蛋白25抗體 |
別 名 | cdc25A (Phospho Thr507); cdc25A (Phospho T507); Cdc 25a; CDC25A2; Cell division cycle 25 homolog A (S. pombe); Cell division cycle 25A; Cell division cycle 25A isoform a; Cell division cycle 25A isoform b; D9Ertd393e; Dual specificity phosphatase CDC25A; EC 3.1.3.48; M phase inducer phosphatase 1; MGC115549; CDC25A; CDC25A2 CAG isoform; M-phase inducer phosphatase 1; MPIP1_HUMAN. |
規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買(mǎi) 大包裝/詢價(jià) |
說(shuō) 明 書(shū) | 100ul |
產(chǎn)品類(lèi)型 | 磷酸化抗體 |
研究領(lǐng)域 | 細(xì)胞生物 信號(hào)轉(zhuǎn)導(dǎo) 細(xì)胞凋亡 細(xì)胞周期蛋白 |
抗體來(lái)源 | Rabbit |
克隆類(lèi)型 | Polyclonal |
交叉反應(yīng) | Mouse, (predicted: Human, Rat, Chicken, Dog, Cow, ) |
產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 59kDa |
性 狀 | Lyophilized or Liquid |
濃 度 | 1mg/ml |
免 疫 原 | KLH conjugated Synthesised phosphopeptide derived from human cdc25A around the phosphorylation site of Thr506 [SR(p-T)WA] |
亞 型 | IgG |
純化方法 | affinity purified by Protein A |
儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
產(chǎn)品介紹 |
background: CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Function: Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDK1 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in vitro. Subunit: Interacts with CCNB1/cyclin B1. Interacts with YWHAE/14-3-3 epsilon when phosphorylated. Interacts with CUL1 specifically when CUL1 is neddylated and active. Interacts with BTRC/BTRCP1 and FBXW11/BTRCP2. Interactions with CUL1, BTRC and FBXW11 are enhanced upon DNA damage. Interacts with PIM1. Interacts with CHEK2; mediates CDC25A phosphorylation and degradation in response to infrared-induced DNA damages. Post-translational modifications: Phosphorylated by CHEK1 on Ser-76, Ser-124, Ser-178, Ser-279, Ser-293 and Thr-507 during checkpoint mediated cell cycle arrest. Also phosphorylated by CHEK2 on Ser-124, Ser-279, and Ser-293 during checkpoint mediated cell cycle arrest. Phosphorylation on Ser-178 and Thr-507 creates binding sites for YWHAE/14-3-3 epsilon which inhibits CDC25A. Phosphorylation on Ser-76, Ser-124, Ser-178, Ser-279 and Ser-293 may also promote ubiquitin-dependent proteolysis of CDC25A by the SCF complex. Phosphorylation of CDC25A at Ser-76 by CHEK1 primes it for subsequent phosphorylation at Ser-79, Ser-82 and Ser-88 by NEK11. Phosphorylation by NEK11 is required for BTRC-mediated polyubiquitination and degradation. Phosphorylation by PIM1 leads to an increase in phosphatase activity. Phosphorylated by PLK3 following DNA damage, leading to promote its ubiquitination and degradation. Ubiquitinated by the anaphase promoting complex/cyclosome (APC/C) ubiquitin ligase complex that contains FZR1/CDH1 during G1 phase leading to its degradation by the proteasome. Ubiquitinated by a SCF complex containing BTRC and FBXW11 during S phase leading to its degradation by the proteasome. Deubiquitination by USP17L2/DUB3 leads to its stabilization. Similarity: Belongs to the MPI phosphatase family. Contains 1 rhodanese domain. Database links: Entrez Gene: 993 Human Entrez Gene: 12530 Mouse Omim: 116947 Human SwissProt: P30304 Human SwissProt: P48964 Mouse Unigene: 437705 Human Unigene: 307103 Mouse Unigene: 11390 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. CDC25家族的組成哺乳動(dòng)物中CDC25家族一共包括3種同源異構(gòu)體(CDC25A、CDC25B、CDC25C),約有50%的序列同源,是一組在細(xì)胞周期調(diào)控中發(fā)揮巨大作用的蘇/酪氨酸雙功能酶 。不同的CDC25家族蛋白在細(xì)胞周期中的作用時(shí)相亦有差異,CDC25A和CDC25C分別在S期和M期發(fā)揮主要作用。 |
| 黄色视频免费久久久久 | 中文字幕一二三区 | 少妇怪性BBB搡BBB | 五月丁香深爱五月五月婷婷淫淫网 | 成人A片无码永久免费第三集 | 91午夜人妻熟女嗷嗷嗷 | 久久人妻少妇嫩草AV蜜桃漫画 | 亚洲色精品三区二区一区 | 在线观看一区二区三区四区 | 久久久久久免费免费麻辣 | 少妇毛片一区二区三区粉嫩aV | 少妇高潮A片无套内谢 | 国产精品ThePorn入口 | 国产精品秘 ThePorn | 黄色三级国产色情无码 | 在线免费观看一级毛片 | 国产亲子乱婬一级A片 | 91人妻边做边打电话AⅤ | 免费体验爆乳美女爱爱视频 | 波多野结衣午夜福利 | 久久露脸国语精品国产91 | 中国偷拍老肥熟露脸视频 | 在线免费观看黄片视频 | 国产精品国产三级国产播12软件 | 无套内谢少妇毛片A片999 | 人妻偷国产拍网曝门91 | 亚洲国产高清视频在线观看 | 国产做受6高潮A片91 | 亚洲一本在线电影av | 中文无码视频在线播放 | 国产日韩免费高清视频 | 四川女人毛多水多A片 | 亚洲免费在线观看 | 丰满岳乱妇毛片高清码成人 | 无码成人精品区一级毛片 | 国产日产欧美一级A片 | 一级婬片A片AAAA毛片A级 | 黄色高清无码在线观看 | av网站在线播放 | 91精品国产乱码A片 日本黑人乱偷人妻中文 |