產(chǎn)品編號(hào) | bs-0395R-PE-Cy7 |
英文名稱 | Rabbit Anti-CD133/PE-Cy7 Conjugated antibody |
中文名稱 | PE-Cy7標(biāo)記的造血干細(xì)胞抗原CD133抗體 |
別 名 | AC133; Antigen AC133; Hematopoietic stem cell antigen; hProminin; PROM1; Prominin I; Prominin like protein 1 precursor; Prominin mouse like 1; prominin1; PROML1; CD133; CORD12; MCDR2; MSTP061; PROML1; RP41; STGD4; PROM1_HUMAN; CD133 antigen. |
規(guī)格價(jià)格 | 100ul/2980元 購買 大包裝/詢價(jià) |
說 明 書 | 100ul |
研究領(lǐng)域 | 腫瘤 細(xì)胞生物 免疫學(xué) 干細(xì)胞 細(xì)胞類型標(biāo)志物 |
抗體來源 | Rabbit |
克隆類型 | Polyclonal |
交叉反應(yīng) | Human, Mouse, (predicted: Rat, ) |
產(chǎn)品應(yīng)用 | Flow-Cyt=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 95kDa |
性 狀 | Lyophilized or Liquid |
濃 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human CD133 |
亞 型 | IgG |
純化方法 | affinity purified by Protein A |
儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
產(chǎn)品介紹 |
background: This gene encodes a pentaspan transmembrane glycoprotein. The protein localizes to membrane protrusions and is often expressed on adult stem cells, where it is thought to function in maintaining stem cell properties by suppressing differentiation. Mutations in this gene have been shown to result in retinitis pigmentosa and Stargardt disease. Expression of this gene is also associated with several types of cancer. This gene is expressed from at least five alternative promoters that are expressed in a tissue-dependent manner. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009] Function: Binds cholesterol in cholesterol-containing plasma membrane microdomains. Proposed to play a role in apical plasma membrane organization of epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner. Subunit: Interacts with CDHR1 and with actin filaments. Subcellular Location: Cell projection, cilium, photoreceptor outer segment. Isoform 1: Apical cell membrane; Multi-pass membrane protein. Cell projection, microvillus membrane; Multi-pass membrane protein. Note=Found in extracellular membrane particles in various body fluids such as cerebrospinal fluid, saliva, seminal fluid and urine. Tissue Specificity: Isoform 1 is selectively expressed on CD34 hematopoietic stem and progenitor cells in adult and fetal bone marrow, fetal liver, cord blood and adult peripheral blood. Isoform 1 is not detected on other blood cells. Isoform 1 is also expressed in a number of non-lymphoid tissues including retina, pancreas, placenta, kidney, liver, lung, brain and heart. Found in saliva within small membrane particles. Isoform 2 is predominantly expressed in fetal liver, skeletal muscle, kidney, and heart as well as adult pancreas, kidney, liver, lung, and placenta. Isoform 2 is highly expressed in fetal liver, low in bone marrow, and barely detectable in peripheral blood. Isoform 2 is expressed on hematopoietic stem cells and in epidermal basal cells (at protein level). Expressed in adult retina by rod and cone photoreceptor cells (at protein level). Post-translational modifications: Isoform 1 and isoform 2 are glycosylated. DISEASE: Defects in PROM1 are the cause of retinitis pigmentosa type 41 (RP41) [MIM:612095]; also known as retinal degeneration autosomal recessive prominin-related. RP is a retinal dystrophy belonging to the group of pigmentary retinopathies. RP is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. Defects in PROM1 are the cause of cone-rod dystrophy type 12 (CORD12) [MIM:612657]. CORD12 is an inherited retinal dystrophy characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa. Defects in PROM1 are the cause of Stargardt disease type 4 (STGD4) [MIM:603786]. Stargardt disease is the most common hereditary macular degeneration. It is characterized by decreased central vision, atrophy of the macula and underlying retinal pigment epithelium, and frequent presence of prominent flecks in the posterior pole of the retina. Defects in PROM1 are the cause of retinal macular dystrophy type 2 (MCDR2) [MIM:608051]. MCDR2 is a bull's-eye macular dystrophy characterized by bilateral annular atrophy of retinal pigment epithelium at the macula. Similarity: Belongs to the prominin family. Database links: Entrez Gene: 8842 Human Entrez Gene: 19126 Mouse Omim: 604365 Human SwissProt: O43490 Human SwissProt: O54990 Mouse Unigene: 614734 Human Unigene: 6250 Mouse Unigene: 144589 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 干細(xì)胞標(biāo)志物 一般認(rèn)為,VEGFR2(血管內(nèi)皮生長因子受體2)是HSCs(造血干細(xì)胞)的特異性的表面標(biāo)志。近來經(jīng)研究發(fā)現(xiàn)CD133分子是HSCs(造血干細(xì)胞)特異性標(biāo)志。CD133即AC133,是一個(gè)新發(fā)現(xiàn)的HSCs(造血干細(xì)胞)表面標(biāo)志,在HSCs(造血干細(xì)胞)分化成熟過程中,CD133的含量迅速降低。EPCs(血管內(nèi)皮前體細(xì)胞)區(qū)別于成熟內(nèi)皮細(xì)胞的主要標(biāo)志是CD133。 經(jīng)研究發(fā)現(xiàn)內(nèi)皮細(xì)胞不能結(jié)合CD133的抗體。證實(shí)分化成熟的內(nèi)皮細(xì)胞不具有CD133。這些說明CD133可以作為EPCs(血管內(nèi)皮前體細(xì)胞)區(qū)別于成熟內(nèi)皮細(xì)胞的一個(gè)表面標(biāo)志. |
| 久久久久久久女国产乱让韩 | 国产黄色在线视频 | 亚州色图视频在线 | 波多野结衣免费观看靠比网站 | 苍井空亚洲精品AA片在线播放 | 国产又粗又黄又爽 | 一区二区在线视频观看 | 欧美毛片少妇 蜜挑 | 国产女教师一区二区三区 | 国产高清无码不卡黄色电影 | 少一女乱一交一精一品 | 国产婬片lA片久久久久久动漫 | 国产精品久久久久久五月天加勒比 | 丰满少妇久久久久久久 | 红杏A片视频网站入口 | 久久久久久久综合影视 | 97丨牛牛丨国产人妻 | 大胆国模一区二区三区 | 人妻一卡二卡欧美视频 | 国产精品久久久久的角色 | 蜜桃秘 AV导航 | 亚洲老女人性生交视频在线 | 国产一级A片无码免费下载樱花 | 搡BBBB搡BBB搡我瞎了 | 国产午夜精品一区二区三区牛牛 | 欧美一区二区视频三区 | 精品A片成人国产一区 | 亚洲熟妇白浆无码AV在线 | 中文字幕av永久免费在线 | 美女草草视频高清在线播放 | 国产乱码一区二区三区的区别 | 99久久成人黄色电影 | 国产高清免费在线观看 | 中文字幕亚洲熟妇熟色av | 特级毛片电影免费免费看不收钱 | 成人3D动漫一区二区三区91 | 强辱丰满人妻HD中文字幕 | 亚洲AV成人片色在线观看高潮 | 国产无人区码熟妇毛片多 | 免费做a爰片久久毛片A片 |