| 產(chǎn)品編號 | bs-1859R-BF488 |
| 英文名稱 | Rabbit Anti-NGB/BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的腦紅蛋白/神經(jīng)血紅蛋白/神經(jīng)球蛋白抗體 |
| 別 名 | neuroglobin; NGB; NGB_MOUSE. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) 細(xì)胞凋亡 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Rat, (predicted: Human, Mouse, Pig, Cow, Rabbit, ) |
| 產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 17kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from mouse NGB |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: This gene encodes an oxygen-binding protein that is distantly related to members of the globin gene family. It is highly conserved among other vertebrates. It is expressed in the central and peripheral nervous system where it may be involved in increasing oxygen availability and providing protection under hypoxic/ischemic conditions. [provided by RefSeq, Jul 2008] Function: Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated form exhibits nitrite reductase activity inhibiting cellular respiration via NO-binding to cytochrome c oxidase. Involved in neuroprotection during oxidative stress. May exert its anti-apoptotic activity by acting to reset the trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis. Subunit: Monomer. Homodimer and homotetramer; disulfide-linked. Subcellular Location: Perikaryon. Tissue Specificity: Predominantly expressed in brain, the strongest expression is seen in the frontal lobe, the subthalamic nucleus and the thalamus. Post-translational modifications: A redox disulfide bond regulates the heme pocket coordination and the rate of nitrite reduction to NO. Phosphorylated in vitro by ERK1, ERK2 and PKA, and in vivo during hypoxia. Phosphorylation increases nitrite reductase activity. Similarity: Belongs to the globin family. Database links: Entrez Gene: 58157 Human Entrez Gene: 64242 Mouse Omim: 605304 Human SwissProt: Q9NPG2 Human SwissProt: Q9ER97 Mouse Unigene: 274363 Human Unigene: 64645 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Neuroglobin是一種在神經(jīng)組織和神經(jīng)沖動中攜氧、轉(zhuǎn)運氧氣和供氧的特異性蛋白,并和神經(jīng)組織微循環(huán)有關(guān),神經(jīng)球蛋白能在缺氧的環(huán)境下保護(hù)神經(jīng)元. |
