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Rabbit Anti-RGS2/Gold Conjugated antibody (bs-0492R-Gold)
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說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-0492R-Gold
英文名稱 Rabbit Anti-RGS2/Gold Conjugated antibody
中文名稱 膠體金標(biāo)記的G蛋白信號(hào)轉(zhuǎn)導(dǎo)調(diào)節(jié)因子2抗體
別    名 Basic helix-loop-helix phosphoprotein G0S8; Cell growth inhibiting protein 31; Cell growth-inhibiting gene 31 protein; G0 to G1 switch regulatory 8 24kD; G0/G1 switch regulatory protein 8; GOS8; OTTHUMP00000060765; Regulator of G protein signaling 2; Regulator of G protein signalling 2 24kD; Regulators of G protein signaling XRGSVI; RGS 2.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul(10nm  15nm  35nm
研究領(lǐng)域 免疫學(xué)  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  生長因子和激素  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Sheep, )
產(chǎn)品應(yīng)用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 24kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human RGS2
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 2 belongs to this family. The protein acts as a mediator of myeloid differentiation and may play a role in leukemogenesis. [provided by RefSeq].

Function:
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. May play a role in leukemogenesis. Plays a role in negative feedback control pathway for adenylyl cyclase signaling. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein.

Subunit:
Interacts with EIF2B5. Interacts with PRKG1 (isoform alpha).

Subcellular Location:
Isoform 1: Cell membrane. Cytoplasm. Nucleus, nucleolus.
Isoform 2: Cell membrane. Cytoplasm. Nucleus, nucleolus.
Isoform 3: Cell membrane. Cytoplasm. Nucleus, nucleolus.
Isoform 4: Cell membrane. Mitochondrion.

Tissue Specificity:
Expressed in acute myelogenous leukemia (AML) and in acute lymphoblastic leukemia (ALL).

Post-translational modifications:
Phosphorylated by protein kinase C. Phosphorylation by PRKG1 leads to activation of RGS2 activity.

Similarity:
Contains 1 RGS domain.

Database links:

Entrez Gene: 5997 Human

Entrez Gene: 19735 Mouse

Entrez Gene: 84583 Rat

Omim: 600861 Human

SwissProt: P41220 Human

SwissProt: O08849 Mouse

SwissProt: Q9JHX0 Rat

Unigene: 78944 Human

Unigene: 28262 Mouse

Unigene: 1892 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

G蛋白信號(hào)轉(zhuǎn)導(dǎo)調(diào)節(jié)子2(RGS2)是動(dòng)物機(jī)體中神經(jīng)、激素及外界信號(hào)刺激轉(zhuǎn)導(dǎo)的重要信號(hào)分子,它作為G蛋白分子開關(guān),在廣泛地協(xié)調(diào)胞外刺激應(yīng)答中起著重要的作用。
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