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Rabbit Anti-FBXO39/BF647 Conjugated antibody (bs-1308R-BF647)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-1308R-BF647
英文名稱 Rabbit Anti-FBXO39/BF647 Conjugated antibody
中文名稱 BF647標記的XIAP相關(guān)因子1凋亡抑制蛋白抗體
別    名 XIAP-associated factor 1; BIRC 4 binding protein; BIRC4-binding protein; XAF1; XAF1_MOUSE; XIAPAF1; BIRC 4 binding protein; BIRC4 binding protein; BIRC4BP; HSXIAPAF 1; HSXIAPAF1; XAF 1; XIAP associated factor 1; Fbxo39; RP24-450M24.4.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 細胞生物  免疫學  細胞凋亡  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Mouse, Rat, 
產(chǎn)品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 31kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from mouse XAF1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
XAF1 binds to XIAP, an inhibitor of caspases-3, -7, and -9, and triggers its relocation from the cytosol to the nucleus. Overexpression of XAF1 results in the neutralization of XIAP's ability to inhibit cell death. XAF1 is normally expressed in all adult and fetal tissues but is present at very low levels in a variety of cancer cell lines. In contrast, XIAP levels have been shown to be high in a majority of cell lines. Low XAF1 and high basal expression of XIAP may therefore play a critical role in maintaining survival of cancer cell lines.

Function:
Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti-caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha-induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondra, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm. The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin; the process requires the E3 ligase activity of BIRC4. Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL. May be a tumor suppressor by mediating apoptosis resistance of cancer cells (By similarity).

Subunit:
Interacts with BIRC1, BIRC2, BIRC3, BIRC4, BIRC7 and BIRC8. Part of an complex consisting of BIRC4, XAF1 and BIRC5; the complex formation requires IFN-beta stimulation (By similarity).

Subcellular Location:
Cytoplasm (By similarity). Nucleus (By similarity). Mitochondrion (By similarity).

Similarity:
Contains 1 TRAF-type zinc finger.

Database links:

Entrez Gene: 628100 Mouse

Entrez Gene: 162517 Human

Omim: 609106 Human

SwissProt: Q8N4B4 Human

SwissProt: Q5NBU5 Mouse

Unigene: 368364 Human

Unigene: 390365 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

XAF1是一個新近發(fā)現(xiàn)的通過與XIAP直接結(jié)合拮抗其抗凋亡作用的蛋白因子。XAF1是一個新的腫瘤抑制基因,XAF1在多種腫瘤細胞和組織中存在低表達或表達缺失。其過度表達可誘導凋亡,抑制腫瘤生長。
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