| 產(chǎn)品編號(hào) | bs-20586R |
| 英文名稱 | CYP3A1 Rabbit pAb |
| 中文名稱 | 細(xì)胞色素CYP3A1抗體 |
| 別 名 | Cytochrome P450 3A1; CYP3A; CYP3A1; cytochrome P450, family 3, subfamily a, polypeptide 1; glucocorticoid inducible P450; HLP; MGC126680; NF 25; NF25; Nifedipine oxidase; Niphedipine oxidase; P450 III steroid inducible; P450 PCN(PCNC inducible); P450 PCN1 |
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Specific References (2) | bs-20586R has been referenced in 2 publications.
[IF=4.36] Xiangling Feng. et al. Inhibitory effects of traditional Chinese medicine colquhounia root tablet on the pharmacokinetics of tacrolimus in rats. J ETHNOPHARMACOL. 2022 Aug;294:115358 WB ; Rat.
[IF=1.785] Hongfang Li. et al. Effects of Xiaochaihu decoction on the expression of cytochrome P450s in rats. Exp Ther Med. 2021 Jun;21(6):1-9 WB ; Rat.
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| 研究領(lǐng)域 | 腫瘤 心血管 細(xì)胞生物 信號(hào)轉(zhuǎn)導(dǎo) 新陳代謝 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Rat |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 57 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞漿 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from rat CYP3A1: 231-330/504 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
CYP3A proteins are P450 monooxygenases and in animals, P450 enzymes serve two major functions: biosynthesis of steroids, fatty acids and bile acids, and the metabolism of endogenous and exogenous substrates. A wide variety of exogenous substrates are metabolized by P450 enzymes, including toxins and drugs. The four major families involved in drug metabolism are CYP1, 2, 3 and 4. The hepatic CYP3A1 protein is detected throughout ciliated and nonciliated cells in seven-day-old rats, and is only detected in the apex of these cells in adult rats. Rat CYP3A1 and CYP3A2 share 89% homolgy, but differ by three out of five of their C-terminal residues. Function: In animals, P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs. The four major families involved in drug metabolism are CYP 1,2,3, and 4. Cytochrome P450 3A4 [human-3A1 Rat] is abundantly expressed in liver and small intestine and is inducible by barbiturates, glucocorticoids and rifampicin. Subcellular Location: Endoplasmic reticulum, membrane bound. Post-translational modifications: Polyubiquitinated in the presence of AMFR and UBE2G1 and alsoSTUB1/CHIP and UBE2D1 (in vitro). Similarity: Belongs to the cytochrome P450 family. SWISS: P04800 Gene ID: 25642 Database links: |
| 產(chǎn)品圖片 |
Sample:
Liver (Rat)Lysate at 40 ug
Cerebrum (Rat)Lysate at 40 ug
Primary: Anti-CYP3A1(bs-20586R)at 1/300 dilution
Secondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilution
Predicted band size: 57kD
Observed band size: 57kD
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