| 產(chǎn)品編號 | bs-12392R |
| 英文名稱 | AES Rabbit pAb |
| 中文名稱 | gp130結(jié)合蛋白GAM抗體 |
| 別 名 | Aes 1; Amino-terminal enhancer of split; Aes 2; aes; AES_HUMAN; Aes1; Aes2; Amino Enhancer of Split; Amino terminal enhancer of split; Amino-terminal enhancer of split; Esp 1; Esp1; Gp130 associated protein GAM; Gp130-associated protein GAM; GRG 5; GRG; GRG protein; GRG5; Protein ESP 1; Protein ESP1; Protein GRG; TLE 5; TLE5. |
| 研究領(lǐng)域 | 細胞生物 信號轉(zhuǎn)導(dǎo) 干細胞 轉(zhuǎn)錄調(diào)節(jié)因子 表觀遺傳學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Sheep,Cow,Chicken) |
| 產(chǎn)品應(yīng)用 | ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 22 kDa |
| 檢測分子量 | |
| 細胞定位 | 細胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TLE5/Amino-terminal enhancer of split: 21-120/197 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
TLE5 is a 197 amino acid nuclear protein that belongs to the TLE family. Expressed predominately in fetal brain, liver, lung, heart and kidney and in adult muscle, TLE5 functions as either a homooligomer or a heterooligomer with other TLE family members and, through this association, dominantly represses the expression of TLE genes. In addition, TLE5 can repress NFkB-regulated gene expression and is thought to play an important role in initiating and maintaining cell differentiation events. Two isoforms of TLE5 exist due to alternative splicing events. Function: Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Subunit: Homooligomer and heterooligomer with other family members. Binds TCF7 (By similarity). Binds the NF-kappa-B subunit RELA. Interacts with PHF12. Subcellular Location: Nucleus. Tissue Specificity: Found predominantly in muscle, heart and Placenta. In fetal tissues, abundantly expressed in the heart, lung, kidney, brain and liver. Post-translational modifications: Ubiquitinated by XIAP/BIRC4. Similarity: Belongs to the WD repeat Groucho/TLE family. SWISS: Q08117 Gene ID: 166 Database links: Entrez Gene: 166 Human Entrez Gene: 14797 Mouse Omim: 600188 Human SwissProt: Q08117 Human SwissProt: P63002 Mouse Unigene: 515053 Human Unigene: 180013 Mouse Unigene: 11495 Rat |
