| 產(chǎn)品編號 | bs-12291R |
| 英文名稱 | SPAG6 Rabbit pAb |
| 中文名稱 | 精子相關(guān)抗原6抗體 |
| 別 名 | PF16; PF16 protein homolog; Protein PF16 homolog; Repro SA 1; Repro-SA-1; SPAG6; SPAG6_HUMAN; Sperm associated antigen 6; Sperm flagellar protein; Sperm-associated antigen 6. |
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Specific References (2) | bs-12291R has been referenced in 2 publications.
[IF=3.905] Fen Xu. et al. Lipoxin A4 and its analog attenuate high fat diet-induced atherosclerosis via Keap1/Nrf2 pathway. Exp Cell Res. 2022 Mar;412:113025 IF ; Rat.
[IF=2.884] Rong Bai. et al. SPAG6 c.900 T>C affects boar semen quality and blood–testis barrier function by creating a new splice acceptor site. ANIM GENET. 2023 May;: WB,ICC ; Pig.
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| 研究領(lǐng)域 | 發(fā)育生物學(xué) 干細(xì)胞 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Pig,Cow,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 55 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SPAG6: 233-290/509 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from an infertile man. This protein localizes to the tail of permeabilized human sperm and contains eight contiguous armadillo repeats, a motif known to mediate protein-protein interactions. Studies in mice suggest that this protein is involved in sperm flagellar motility and maintenance of the structural integrity of mature sperm. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]. Function: Important for structural integrity of the central apparatus in the sperm tail and for flagellar motility. Subunit: Interacts with SPAG16 and SPAG17 (By similarity). Subcellular Location: Cytoplasm, cytoskeleton. Cell projection, cilium, flagellum. Note=Associated with microtubules. Detected on the sperm flagellum. Tissue Specificity: Highly expressed in testis. Similarity: Contains 8 ARM repeats. SWISS: O75602 Gene ID: 9576 Database links: Entrez Gene: 9576 Human Entrez Gene: 50525 Mouse Entrez Gene: 734748 Xenopus laevis Entrez Gene: 548730 Xenopus tropicalis Omim: 605730 Human SwissProt: O75602 Human SwissProt: Q9JLI7 Mouse |
