| 產(chǎn)品編號(hào) | bs-11821R |
| 英文名稱 | CRMP3 Rabbit pAb |
| 中文名稱 | 二氫嘧啶酶相關(guān)蛋白3抗體 |
| 別 名 | Collapsin response mediator protein 3; CRMP 3; CRMP-3; CRMP3; Dihydropyrimidinase like 4; Dihydropyrimidinase related protein 4; Dihydropyrimidinase-related protein 4; DPYL4_HUMAN; DPYSL4; DRP 4; DRP-4; DRP4; ULIP 4; ULIP-4; ULIP4; UNC33 like phosphoprote |
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Specific References (1) | bs-11821R has been referenced in 1 publications.
[IF=3.171] Zhi-Sheng Ji. et al. Spastin interacts with collapsin response mediator protein 3 to regulate neurite growth and branching. Neural Regen Res. 2021 Apr;16(12):2549 IP ; Rat.
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| 研究領(lǐng)域 | 細(xì)胞生物 神經(jīng)生物學(xué) |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human,Mouse (predicted: Rat,Cow) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 62 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CRMP3: 6-100/572 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Collapsin response mediator proteins (CRMPs), including CRMP-1 (DRP-1), CRMP-2 (DRP-2 or TOAD64), CRMP-3 (DRP-4), CRMP-4 (DRP-3) and CRMP-5 (DRP-5), mediate signal transduction after exposure of neural cells to the axon guidance molecule Semaphorin 3A (SEMA3A)/collapsin. CRMPs are present in the developing cerebral cortex and neocortical neurons and are responsive to SEMA3A. In the adult brain, the expression of CRMPs is dramatically downregulated. However, they remain expressed in structures that retain their capacity for differentiation and plasticity. CRMP-3 is expressed transiently in developing spinal cord and selectively in the postnatal cerebellum. It is cleaved by Calpain to produce a p54 N-terminal fragment. This cleavage product translocates to the nucleus and induces neuronal death in response to excitotoxicity and cerebral ischemia. Function: Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration. Subcellular Location: Cytoplasm. Tissue Specificity: Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily. SWISS: O14531 Gene ID: 10570 Database links: Entrez Gene: 10570 Human Entrez Gene: 26757 Mouse Omim: 608407 Human SwissProt: O14531 Human SwissProt: O35098 Mouse Unigene: 100058 Human Unigene: 250414 Mouse Unigene: 10503 Rat |
| 產(chǎn)品圖片 |
Sample:
Ovary(Mouse)Lysate at 40 ug
Cerebrum (Mouse)Lysate at 40 ug
Primary: Anti-CRMP3(bs-11821R)at 1/300 dilution
Secondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilution
Predicted band size: 62kD
Observed band size: 62kD
Sample:
DU145 (Human)Cell Lysate at 40 ug
A549 (Human) Cell Lysate at 40 ug
Primary: Anti-CRMP3(bs-11821R)at 1/300 dilution
Secondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilution
Predicted band size: 62kD
Observed band size: 62kD
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