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FAM64A Rabbit pAb (bs-11005R)  
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產(chǎn)品編號 bs-11005R
英文名稱 FAM64A Rabbit pAb
中文名稱 染色體分離調節(jié)蛋白1抗體
別    名 FA64A_HUMAN; FAM64A; family with sequence similarity 64, member A; FLJ10156; FLJ10491; Protein FAM64A; RCS1; regulator of chromosome segregation 1; PIMREG; CALM-interactor expressed in thymus and spleen; PICALM-interacting mitotic regulator; Regulator of   
研究領域 細胞生物  免疫學  神經(jīng)生物學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Mouse (predicted: Human,Rat,Pig,Horse)
產(chǎn)品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 27 kDa
檢測分子量
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human RCS1/FAM64A: 151-248/248 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 PIMREG (PICALM Interacting Mitotic Regulator) is a Protein Coding gene. Diseases associated with PIMREG include Suppurative Periapical Periodontitis.

Function:
During mitosis, may play a role in the control of metaphase-to-anaphase transition.

Subunit:
Isoform 1 and isoform 2 interact with PICALM; this interaction may target PICALM to the nucleus (PubMed:16491119). During mitosis, associates with HDAC2 and MTA2 subunits of the chromatin-remodeling NuRD complex; this association is strongest at prometaphase and decreases as the cell progresses through metaphase and anaphase (PubMed:18757745).

Subcellular Location:
Nucleus

Tissue Specificity:
Expressed in thymus (at protein level). Detected in spleen, colon, ovary and small intestines.

Post-translational modifications:
Ubiquitinated by the anaphase-promoting complex/cyclosome (APC/C) complex in the presence of FZR1, leading to its degradation by the proteasome during mitotic exit. However, degradation is not essential for normal mitotic progression within a single cell cycle.

SWISS:
Q9BSJ6

Gene ID:
54478

Database links:

Entrez Gene: 54478 Human

SwissProt: Q9BSJ6 Human

Unigene: 592116 Human



產(chǎn)品圖片
Sample: Thymus (Mouse) Lysate at 40 ug Spleen (Mouse) Lysate at 40 ug Primary: Anti- FAM64A (bs-11005R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 27 kD Observed band size: 25 kD
Sample: Ovary (Mouse) Lysate at 40 ug Primary: Anti- FAM64A (bs-11005R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 27 kD Observed band size: 27/26 kD
Sample: Thymus(Mouse) Lysate at 40 ug Primary: Anti- FAM64A (bs-11005R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 27 kD Observed band size: 27/26 kD
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