| 產(chǎn)品編號 | bs-9535R |
| 英文名稱 | ATAT1 Rabbit pAb |
| 中文名稱 | α微管蛋白乙酰轉(zhuǎn)移酶1抗體 |
| 別 名 | C6orf134; Acetyltransferase mec 17 homolog; alpha TAT; alpha tubulin acetyltransferase 1; alpha tubulin N acetyltransferase; Chromosome 6 open reading frame 134; Hypothetical protein LOC79969; MEC17; Nbla00487; TAT; ATAT_HUMAN. α-TAT; |
 |
Specific References (2) | bs-9535R has been referenced in 2 publications.
[IF=6.081] José Martínez-Hernández. et al. Crosstalk between acetylation and the tyrosination/detyrosination cycle of α-tubulin in Alzheimer's disease.. FRONT CELL DEV BIOL. 2022 Aug;10:926914-926914 WB ; Mouse.
[IF=5.413] Wang HH et al. Rab23/Kif17 regulate oocyte meiotic progression by modulating tubulin acetylation and actin dynamics. Development. 2019 Feb 4;146(3). WB ; Mouse.
|
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 免疫學(xué) 神經(jīng)生物學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human,Mouse,Rat (predicted: Rabbit,Pig,Sheep,Cow,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 47 kDa |
| 檢測分子量 | |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human alpha-TAT: 1-100/421 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Making up nearly 6% of the human genome, chromosome 6 contains around 1,200 genes within 170 million base pairs of sequence. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer suggesting the presence of a cancer susceptibility locus. Porphyria cutanea tarda is associated with chromosome 6 through the HFE gene which, when mutated, predisposes an individual to developing this porphyria. Notably, the PARK2 gene, which is associated with Parkinson's disease, and the genes encoding the major histocompatiblity complex proteins, which are key molecular components of the immune system and determine predisposition to rheumatic diseases, are also located on chromosome 6. Stickler syndrome, 21-hydroxylase deficiency and maple syrup urine disease are also associated with genes on chromosome 6. A bipolar disorder susceptibility locus has been identified on the q arm of chromosome 6. The C6orf134 gene product has been provisionally designated C6orf134 pending further characterization. Function: Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. May affect microtubule stability and regulate microtubule dynamics. May be involved in neuron development. Similarity: Belongs to the acetyltransferase ATAT1 family. SWISS: Q9H8X5 Gene ID: 79969 Database links: Entrez Gene: 79969 Human Entrez Gene: 73242 Mouse SwissProt: Q9H8X5 Human SwissProt: Q8K341 Mouse |
| 產(chǎn)品圖片 |
Sample:
Lane 1: Mouse Cerebrum tissue lysates
Lane 2: Rat Cerebrum tissue lysates
Primary: Anti-ATAT1 (bs-9535R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 47 kDa
Observed band size: 47 kDa
Paraformaldehyde-fixed, paraffin embedded (mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (α-TAT) Polyclonal Antibody, Unconjugated (bs-9535R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
|
