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Laminin alpha 1 Rabbit pAb (bs-4973R)  
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產(chǎn)品編號 bs-4973R
英文名稱 Laminin alpha 1 Rabbit pAb
中文名稱 層粘蛋白α1抗體
別    名 LAMA; LAMA1; Laminin A chain; Laminin subunit alpha-1; Laminin-1 subunit alpha; Laminin-3 subunit alpha; S-laminin subunit alpha; S-LAM alpha; Laminin subunit alpha-1; LAMA1_HUMAN; Laminin-1 subunit alpha; Laminin-3 subunit alpha.  Laminin α-1; Laminin α1; Laminin α 1; Laminin subunit α1; Laminin subunit α-1; Laminin alpha-1.
研究領(lǐng)域 細胞生物  神經(jīng)生物學(xué)  信號轉(zhuǎn)導(dǎo)  細胞粘附分子  細胞骨架  細胞外基質(zhì)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse (predicted: Human,Rat,Rabbit,Cow,Chicken)
產(chǎn)品應(yīng)用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 337 kDa
檢測分子量
細胞定位 細胞膜 細胞外基質(zhì) 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Laminin alpha 1: 2201-2400/3075 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 This gene encodes one of the alpha 1 subunits of laminin. The laminins are a family of extracellular matrix glycoproteins that have a heterotrimeric structure consisting of an alpha, beta and gamma chain. These proteins make up a major component of the basement membrane and have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Mutations in this gene may be associated with Poretti-Boltshauser syndrome. [provided by RefSeq, Sep 2014].

Function:
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

Subunit:
Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Alpha-1 is a subunit of laminin-1 (laminin-111 or EHS laminin) and laminin-3 (laminin-121 or S-laminin).

Subcellular Location:
Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component.

Similarity:
Contains 17 laminin EGF-like domains.
Contains 5 laminin G-like domains.
Contains 2 laminin IV type A domains.
Contains 1 laminin N-terminal domain.

SWISS:
Q9Y6N6

Gene ID:
3918

Database links:

Entrez Gene: 10319 Human

Entrez Gene: 284217 Human

Entrez Gene: 3908 Human

Entrez Gene: 3912 Human

Entrez Gene: 3913 Human

Entrez Gene: 3915 Human

Entrez Gene: 3918 Human

Entrez Gene: 16772 Mouse

Entrez Gene: 316758 Rat

Omim: 150320 Human

SwissProt: P07942 Human

SwissProt: P24043 Human

SwissProt: P25391 Human

SwissProt: P55268 Human

SwissProt: Q9Y6N6 Human

SwissProt: P19137 Mouse

SwissProt: Q9R0B6 Mouse

Unigene: 201805 Human

Unigene: 270364 Human

Unigene: 302362 Mouse



產(chǎn)品圖片
Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Laminin alpha 1) Polyclonal Antibody, Unconjugated (bs-4973R) at 1:500 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.
Paraformaldehyde-fixed, paraffin embedded (mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Laminin alpha 1) Polyclonal Antibody, Unconjugated (bs-4973R) at 1:400 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.
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