| 產(chǎn)品編號(hào) | bs-9469R |
| 英文名稱 | IRX5 Rabbit pAb |
| 中文名稱 | Iroquois同源蛋白5抗體 |
| 別 名 | Homeodomain protein IRX-2A; Homeodomain Protein IRXB2; Iroquois Homeobox Protein 5; Iroquois-class homeodomain protein IRX-5; IRX2A; Irx5; IRX5_HUMAN; IRXB2. |
| 研究領(lǐng)域 | 心血管 細(xì)胞生物 神經(jīng)生物學(xué) 轉(zhuǎn)錄調(diào)節(jié)因子 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse,Rat (predicted: Human,Rabbit,Pig,Chicken,Dog) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 50 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 細(xì)胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human IRX5: 151-250/483 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Establishes the cardiac repolarization gradient by its repressive actions on the KCND2 potassium-channel gene. Required for retinal cone bipolar cell differentiation. May regulate contrast adaptation in the retina and control specific aspects of visual function in circuits of the mammalian retina (By similarity). Could be involved in the regulation of both the cell cycle and apoptosis in prostate cancer cells. Function: Establishes the cardiac repolarization gradient by itsrepressive actions on the KCND2 potassium-channel gene. Requiredfor retinal cone bipolar cell differentiation. May regulatecontrast adaptation in the retina and control specific aspects ofvisual function in circuits of the mammalian retina (Bysimilarity). Could be involved in the regulation of both the cellcycle and apoptosis in prostate cancer cells. Involved incraniofacial and gonadal development. Modulates the migration ofprogenitor cell populations in branchial arches and gonads byrepressing CXCL12. Subcellular Location: Nucleus. DISEASE: Defects in IRX5 are the cause of Hamamy syndrome (HMMS)[MIM:611174]. A sydrome characterized by severe hypertelorism,upslanting palpebral fissures, brachycephaly, abnormal ears,sloping shoulders, enamel hypoplasia, and osteopenia with repeatedfractures. Additional features include myopia, mild to moderatesensorineural hearing loss, gonadal anomalies, and borderlineintelligence. Similarity: Belongs to the TALE/IRO homeobox family. Contains 1 homeobox DNA-binding domain. SWISS: P78411 Gene ID: 10265 Database links: Entrez Gene: 10265 Human Entrez Gene: 54352 Mouse Omim: 606195 Human SwissProt: A2RRB5 Human SwissProt: P78411 Human SwissProt: Q9JKQ4 Mouse Unigene: 435730 Human Unigene: 101153 Mouse |
| 產(chǎn)品圖片 |
Paraformaldehyde-fixed, paraffin embedded (Rat kidney); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (IRX5) Polyclonal Antibody, Unconjugated (bs-9469R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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