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EP4 Rabbit pAb (bs-8538R)  
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產(chǎn)品編號 bs-8538R
英文名稱 EP4 Rabbit pAb
中文名稱 前列腺素E受體蛋白4抗體
別    名 Prostaglandin E Receptor EP4; EP 4; EP4; EP-4; EP4R; MGC126583; PE2R4_HUMAN; PGE receptor EP4 subtype; PGE2 receptor EP4 subtype; Prostaglandin E receptor 4; Prostaglandin E receptor 4 subtype EP4; Prostaglandin E2 receptor; Prostaglandin E2 receptor EP4 subtype; Prostanoid EP4 receptor; PTGER 2; PTGER 4; PTGER2; PTGER4.  
Specific References  (8)     |     bs-8538R has been referenced in 8 publications.
[IF=9.423] Xi He. et al. Tumor-initiating stem cell shapes its microenvironment into an immunosuppressive barrier and pro-tumorigenic niche. Cell Rep. 2021 Sep;36:109674  IF ;  mouse.  
[IF=7.01] Xin Wang. et al. Irreversible Electroporation Improves Tendon Healing in a Rat Model of Collagenase-Induced Achilles Tendinopathy. AM J SPORT MED. ;():  IHC,IF ;  Rat.  
[IF=4.622] Seung-Yub Song. et al. Purification of phenoloxidase from Haliotis discus hannai and its anti-inflammatory activity in vitro. FISH SHELLFISH IMMUN. 2023 Jun;137:108741  WB ;  Human.  
[IF=4.5] Koyama, Hiroyuki, et al. "Comprehensive Profiling of GPCR Expression in Ghrelin-producing Cells." Endocrinology (2016): en-2016.  IHC-P ;  Mouse.  
[IF=3.23] Takemiya et al. Microsomal Prostaglandin E Synthase-1 Facilitates an Intercellular Interaction between CD4? T Cells through IL-1β Autocrine Function in Experimental Autoimmune Encephalomyelitis. (2017) Int.J.Mol.Sci. 18  IHC-F ;  Mouse.  
[IF=2.38] Hu, Ruiqi, et al. "The expression of prostaglandin-E2 and its receptor in the oviduct of Chinese brown frog (Rana dybowskii)." Prostaglandins & Other Lipid Mediators (2016).  IHC-P ;  Others.  
[IF=2.253] Chen Z et al. Seasonal expressions of prostaglandin E synthases and receptors in the prostate of the wild ground squirrel (Spermophilus dauricus). Prostaglandins and Other Lipid Mediators 148 (2020) 106412.  IHC-P ;  squirrel.  
[IF=2.253] Wang Y et al. Seasonal expressions of COX-1, COX-2 and EP4 in the uteri of the wild Daurian ground squirrels (Spermophilus dauricus). Prostaglandins Other Lipid Mediat. 2019 Aug;143:106343.  IHC&WB ;  squirrel.  
研究領(lǐng)域 信號轉(zhuǎn)導  G蛋白偶聯(lián)受體  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse
產(chǎn)品應(yīng)用 WB=1:500-2000,Flow-Cyt=2ug/Test
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 53 kDa
檢測分子量
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human EP4R/Prostaglandin E Receptor EP4: 151-250/488 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.

Function:
Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.

Subunit:
Interacts with FEM1A.

Subcellular Location:
Cell membrane.

Tissue Specificity:
High in intestine and in peripheral blood mononuclear cells; low in lung, kidney, thymus, uterus, vasculature and brain. Not found in liver, heart, retina oe skeletal muscle.

Post-translational modifications:
Phosphorylation mediates agonist-mediated desensitization by promoting cytoplasmic retention.

Similarity:
Belongs to the G-protein coupled receptor 1 family.

SWISS:
P35408

Gene ID:
5734

Database links:

Entrez Gene: 5734 Human

Entrez Gene: 19219 Mouse

Entrez Gene: 84023 Rat

Entrez Gene: 443222 Sheep

Omim: 601586 Human

SwissProt: P35408 Human

SwissProt: P32240 Mouse

SwissProt: P43114 Rat

Unigene: 199248 Human

Unigene: 18509 Mouse

Unigene: 16062 Rat



產(chǎn)品圖片
Sample: Lane 1: Mouse Uterus tissue lysates Lane 2: Mouse Small intestine tissue lysates Lane 3: Mouse Kidney tissue lysates Lane 4: Mouse Prostate tissue lysates Primary: Anti-EP4 (bs-8538R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit
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