| 產(chǎn)品編號 | bs-7678R |
| 英文名稱 | DR6 Rabbit pAb |
| 中文名稱 | 腫瘤細(xì)胞調(diào)亡素/腫瘤壞死因子受體死亡受體6抗體 |
| 別 名 | TNFRSF 21; BM 018; BM018; CD358; Death receptor 6; DR 6; MGC31965; TNFR related death receptor 6; TNFRSF21; TNFRSF21 protein; TNR21_HUMAN; Tumor necrosis factor receptor superfamily member 21; Tumor necrosis factor receptor superfamily member 21 precursor |
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Specific References (1) | bs-7678R has been referenced in 1 publications.
[IF=40.137] Strilic, Boris, et al. "Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis." Nature (2016). IF ; Mouse&Human.
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| 研究領(lǐng)域 | 細(xì)胞生物 細(xì)胞凋亡 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse,Rat (predicted: Human,Rabbit,Cow,Chicken,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 52/68 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DR6/CD358: 101-200/655 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
May activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). Tissue specificity: Highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. Detected at lower levels in lung, skeletal muscle, kidney, testis, uterus, small intestine, colon, spleen, bone marrow and fetal liver. Very low levels were found in adult liver and peripheral blood leukocytes. Function: May activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). Subunit: Associates with TRADD. Interacts with N-APP (By similarity). Subcellular Location: Membrane; Single-pass type I membrane protein (Probable). Tissue Specificity: Highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. Detected at lower levels in lung, skeletal muscle, kidney, testis, uterus, small intestine, colon, spleen, bone marrow and fetal liver. Very low levels were found in adult liver and peripheral blood leukocytes. Similarity: Contains 1 death domain. Contains 4 TNFR-Cys repeats. SWISS: O75509 Gene ID: 27242 Database links: Entrez Gene: 27242 Human Omim: 605732 Human SwissProt: O75509 Human Unigene: 443577 Human |
| 產(chǎn)品圖片 |
Sample: Heart (Mouse) Lysate at 40 ug
Primary: Anti-DR6 (bs-7678R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 52/68 kD
Observed band size: 52 kD
Sample:
Heart (Mouse) Lysate at 40 ug
Primary: Anti-DR6 (bs-7678R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 52/68 kD
Observed band size: 52 kD
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