| 產(chǎn)品編號(hào) | bs-7075R |
| 英文名稱 | phospho-PBP (Ser153) Rabbit pAb |
| 中文名稱 | 磷酸化Raf激酶抑制蛋白抗體 |
| 別 名 | PBP(phospho S153); p-PBP(phospho S153); p-RKIP(S153); p-RKIP(Ser153); RKIP(phospho-Ser153); RKIP(phospho-S153); phosphatidylethanolamine-binding protein; PEBP; PBP; Phosphatidylethanolamine-binding protein 1; PEBP-1; PEBP1; Prostatic-binding protein; Prostatic binding protein; Neuropolypeptide h3; HCNPpp; Raf kinase inhibitor protein; Hippocampal cholinergic neurostimulating peptide; HCNP; PEBP1_HUMAN. |
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Specific References (1) | bs-7075R has been referenced in 1 publications.
[IF=6.208] Viviana Tritto. et al. Changes of RAS Pathway Phosphorylation in Lymphoblastoid Cell Lines from Noonan Syndrome Patients Carrying Hypomorphic Variants in Two NS Genes. INT J MOL SCI. 2023 Jan;24(4):4035 WB ; Human.
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| 產(chǎn)品類型 | 磷酸化抗體 |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 信號(hào)轉(zhuǎn)導(dǎo) 細(xì)胞凋亡 轉(zhuǎn)錄調(diào)節(jié)因子 激酶和磷酸酶 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Rabbit,Pig) |
| 產(chǎn)品應(yīng)用 | ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 21 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthesised phosphopeptide derived from human RKIP around the phosphorylation site of Ser153: VA(p-S)FR |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase.
Function: Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation. HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor. Subunit: Has a tendency to form dimers by disulfide cross-linking. Interacts with RAF1 and this interaction is enhanced if RAF1 is phosphorylated on residues 'Ser-338', 'Ser-339', 'Tyr-340' and 'Tyr-341'. Subcellular Location: Cytoplasm. Similarity: Belongs to the phosphatidylethanolamine-binding protein family. SWISS: P30086 Gene ID: 5037 Database links: Entrez Gene: 5037 Human Omim: 604591 Human SwissProt: P30086 Human Unigene: 433863 Human Unigene: 29745 Rat Raf激酶抑制蛋白(PKIP)屬于磷脂酰乙醇胺結(jié)合蛋白（phosphatidylethanolamine-binding protein, PEBP）家族,廣泛存在于各種不同的生物中,PKIP還參與了對(duì)NF-kB信號(hào)通路和G蛋白偶聯(lián)受體信號(hào)通路的調(diào)控,參與NF-κB信號(hào)通路的調(diào)控,參與了對(duì)細(xì)胞內(nèi)多種信號(hào)轉(zhuǎn)導(dǎo)通路的調(diào)節(jié)作用。RKIP在膜的生物合成、精子發(fā)生、神經(jīng)發(fā)育和細(xì)胞凋亡等生理過程中發(fā)揮重要作用，并參與了老年癡呆癥及糖尿病等的病理過程。有學(xué)者認(rèn)為：RKIP有抑制腫瘤細(xì)胞轉(zhuǎn)移的作用。 |
